Liaisons dangereuses: sexual recombination among pathogenic trypanosomes

Wendy Gibson

doi:10.1016/j.resmic.2015.05.005

Liaisons dangereuses: sexual recombination among pathogenic trypanosomes

Wendy Gibson

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Abstract

Sexual recombination between pathogenic microbes has the potential to mobilise genes for harmful traits into new genetic backgrounds creating new pathogen strains. Since 1986 we have known that genetic exchange can occur in trypanosomes, but we are only now starting to unravel details of the process. In Trypanosoma brucei genetic exchange occurs in the tsetse vector, but is not an obligatory part of the life cycle. The process involves meiosis and production of haploid gametes, and thus appears to be true sexual reproduction. This review looks at the experimental evidence concerning genetic exchange and identifies current gaps in our knowledge.

Original language	English
Pages (from-to)	459-466
Number of pages	8
Journal	Research in Microbiology
Volume	166
Issue number	6
Early online date	28 May 2015
DOIs	https://doi.org/10.1016/j.resmic.2015.05.005
Publication status	Published - Jul 2015

Keywords

Trypanosoma brucei
Genetic exchange
Meiosis
Human African trypanosomiasis
Life cycle
Haploid gamete

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10.1016/j.resmic.2015.05.005

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Accepted author manuscript, 618 KBLicence: CC BY-NC-ND

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title = "Liaisons dangereuses: sexual recombination among pathogenic trypanosomes",

abstract = "Sexual recombination between pathogenic microbes has the potential to mobilise genes for harmful traits into new genetic backgrounds creating new pathogen strains. Since 1986 we have known that genetic exchange can occur in trypanosomes, but we are only now starting to unravel details of the process. In Trypanosoma brucei genetic exchange occurs in the tsetse vector, but is not an obligatory part of the life cycle. The process involves meiosis and production of haploid gametes, and thus appears to be true sexual reproduction. This review looks at the experimental evidence concerning genetic exchange and identifies current gaps in our knowledge.",

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AB - Sexual recombination between pathogenic microbes has the potential to mobilise genes for harmful traits into new genetic backgrounds creating new pathogen strains. Since 1986 we have known that genetic exchange can occur in trypanosomes, but we are only now starting to unravel details of the process. In Trypanosoma brucei genetic exchange occurs in the tsetse vector, but is not an obligatory part of the life cycle. The process involves meiosis and production of haploid gametes, and thus appears to be true sexual reproduction. This review looks at the experimental evidence concerning genetic exchange and identifies current gaps in our knowledge.

KW - Trypanosoma brucei

KW - Genetic exchange

KW - Meiosis

KW - Human African trypanosomiasis

KW - Life cycle

KW - Haploid gamete

U2 - 10.1016/j.resmic.2015.05.005

DO - 10.1016/j.resmic.2015.05.005

M3 - Article (Academic Journal)

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SN - 0923-2508

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SP - 459

EP - 466

JO - Research in Microbiology

JF - Research in Microbiology

IS - 6

ER -

Liaisons dangereuses: sexual recombination among pathogenic trypanosomes

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Keywords

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