Lifetime risk of renal replacement therapy in Europe: a population-based study using data from the ERA-EDTA Registry

Jan A.J.G. Van Den Brand*, Maria Pippias, Vianda S. Stel, Fergus J. Caskey, Frederic Collart, Partik Finne, James Heaf, Jean Philippe Jais, Reinhard Kramar, Ziad A. Massy, Johan De Meester, Jamie P. Traynor, Anna Varberg Reisæter, Jack F.M. Wetzels, Kitty J. Jager

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)
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Abstract

Background. Upcoming KDIGO guidelines for the evaluation of living kidney donors are expected to move towards a personal risk-based evaluation of potential donors. We present the age and sex-specific lifetime risk of renal replacement therapy (RRT) for end-stage renal disease in 10 European countries. Methods. We defined lifetime risk of RRT as the cumulative incidence of RRT up to age 90 years. We obtained RRT incidence rates per million population by 5-year age groups and sex using data from the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, and used these to estimate the cumulative incidence of RRT, adjusting for competingmortality risk. Results. Lifetime risk of RRT varied from 0.44% to 2.05% at age 20 years and from 0.17% to 1.59% at age 70 years across countries, and was twice as high in men as in women. Lifetime RRT risk decreased with age, ranging from an average of 0.77% to 0.44% in 20- to- 70-year-old women, and from 1.45% to 0.96% in 20- to- 70-year-old men. The lifetime risk of RRT increased slightly over the past decade, more so in men than in women. However, it appears to have stabilized or even decreased slightly inmore recent years. Conclusions. The lifetime risk of RRT decreased with age, was lower in women as compared with men of equal age and varied considerably throughout Europe. Given the substantial differences in lifetime risk of RRT between the USA and Europe, country-specific estimates should be used in the evaluation and communication of the risk of RRT for potential living kidney donors.

Original languageEnglish
Pages (from-to)348-355
Number of pages8
JournalNephrology Dialysis Transplantation
Volume32
Issue number2
Early online date24 Dec 2016
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • End-stage renal disease
  • Lifetime risk
  • Living kidney donor
  • Mortality
  • Renal replacement therapy

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