Research output per year
Research output per year
Hennie Valkenier, Cally J. E. Haynes, Julie Herniman, Philip A. Gale*, Anthony P. Davis
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Despite extensive interest in transmembrane anion carriers (anionophores), the factors that govern activity are still only partly understood. Herein we report a study which identifies a new principle for anionophore design, that of "lipophilic balance'. A series of simple thioureas with identical molecular formulae has been prepared and assayed for chloride/nitrate transport activity in synthetic vesicles. The molecules differ only in the positioning of the phenylthiourea binding unit within an 11-carbon linear chain. They are shown to possess very similar lipophilicities and anion affinities, while a test for leaching establishes that they locate almost exclusively in the vesicle membranes. Notwithstanding their close similarities, activities across the series show >5-fold variation, peaking when the phenylthiourea group is centrally located. The results suggest that transport is favoured by a balanced array of lipophilic substituents, possibly because this arrangement facilitates transfer of the complexed anion into the apolar membrane interior.
Original language | English |
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Pages (from-to) | 1128-1134 |
Number of pages | 7 |
Journal | Chemical Science |
Volume | 5 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2014 |
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research
Davis, A. P. (Principal Investigator)
10/09/12 → 9/03/16
Project: Research
Davis, A. P. (Principal Investigator)
1/11/08 → 1/03/12
Project: Research
Person: Academic