Liver preservation with UW solution. I. Evidence that hydroxyethyl starch is not essential

B O Howden, P Jablonski, A C Thomas, K Walls, M Biguzas, D F Scott, H Grossman, V C Marshall

Research output: Contribution to journalArticle (Academic Journal)peer-review

48 Citations (Scopus)

Abstract

Preservation of rat livers by simple ice-storage has been demonstrated after 24 hr using the University of Wisconsin (UW) solution. Equally good preservation could be obtained by substituting hydroxyethyl starch (HES) from another source or by omission of HES from the UW formulation. Survival, early and late function, and morphology at the end of a 3-month follow-up period were essentially similar for all three test groups. It is concluded that HES is not required for optimum preservation of the rat liver in this treatment model.

Original languageEnglish
Pages (from-to)869-72
Number of pages4
JournalTransplantation
Volume49
Issue number5
Publication statusPublished - May 1990

Keywords

  • Adenosine
  • Allopurinol
  • Animals
  • Aspartate Aminotransferases
  • Bilirubin
  • Glutathione
  • Hydroxyethyl Starch Derivatives
  • Insulin
  • Liver Transplantation
  • Organ Preservation
  • Organ Preservation Solutions
  • Raffinose
  • Rats
  • Rats, Inbred Strains
  • Solutions
  • Starch
  • Time Factors

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