Liver preservation with UW solution. I. Evidence that hydroxyethyl starch is not essential

B O Howden; P Jablonski; A C Thomas; K Walls; M Biguzas; D F Scott; H Grossman; V C Marshall

Liver preservation with UW solution. I. Evidence that hydroxyethyl starch is not essential

B O Howden, P Jablonski, A C Thomas, K Walls, M Biguzas, D F Scott, H Grossman, V C Marshall

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

3 Citations (Scopus)

Abstract

Preservation of rat livers by simple ice-storage has been demonstrated after 24 hr using the University of Wisconsin (UW) solution. Equally good preservation could be obtained by substituting hydroxyethyl starch (HES) from another source or by omission of HES from the UW formulation. Survival, early and late function, and morphology at the end of a 3-month follow-up period were essentially similar for all three test groups. It is concluded that HES is not required for optimum preservation of the rat liver in this treatment model.

Original language	English
Pages (from-to)	869-72
Number of pages	4
Journal	Transplantation
Volume	49
Issue number	5
Publication status	Published - May 1990

Keywords

Adenosine
Allopurinol
Animals
Aspartate Aminotransferases
Bilirubin
Glutathione
Hydroxyethyl Starch Derivatives
Insulin
Liver Transplantation
Organ Preservation
Organ Preservation Solutions
Raffinose
Rats
Rats, Inbred Strains
Solutions
Starch
Time Factors

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@article{20fea4036917418dadfdff74d33f393c,

title = "Liver preservation with UW solution. I. Evidence that hydroxyethyl starch is not essential",

abstract = "Preservation of rat livers by simple ice-storage has been demonstrated after 24 hr using the University of Wisconsin (UW) solution. Equally good preservation could be obtained by substituting hydroxyethyl starch (HES) from another source or by omission of HES from the UW formulation. Survival, early and late function, and morphology at the end of a 3-month follow-up period were essentially similar for all three test groups. It is concluded that HES is not required for optimum preservation of the rat liver in this treatment model.",

keywords = "Adenosine, Allopurinol, Animals, Aspartate Aminotransferases, Bilirubin, Glutathione, Hydroxyethyl Starch Derivatives, Insulin, Liver Transplantation, Organ Preservation, Organ Preservation Solutions, Raffinose, Rats, Rats, Inbred Strains, Solutions, Starch, Time Factors",

author = "Howden, {B O} and P Jablonski and Thomas, {A C} and K Walls and M Biguzas and Scott, {D F} and H Grossman and Marshall, {V C}",

year = "1990",

month = may,

language = "English",

volume = "49",

pages = "869--72",

journal = "Transplantation",

issn = "0041-1337",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - Liver preservation with UW solution. I. Evidence that hydroxyethyl starch is not essential

AU - Howden, B O

AU - Jablonski, P

AU - Thomas, A C

AU - Walls, K

AU - Biguzas, M

AU - Scott, D F

AU - Grossman, H

AU - Marshall, V C

PY - 1990/5

Y1 - 1990/5

N2 - Preservation of rat livers by simple ice-storage has been demonstrated after 24 hr using the University of Wisconsin (UW) solution. Equally good preservation could be obtained by substituting hydroxyethyl starch (HES) from another source or by omission of HES from the UW formulation. Survival, early and late function, and morphology at the end of a 3-month follow-up period were essentially similar for all three test groups. It is concluded that HES is not required for optimum preservation of the rat liver in this treatment model.

AB - Preservation of rat livers by simple ice-storage has been demonstrated after 24 hr using the University of Wisconsin (UW) solution. Equally good preservation could be obtained by substituting hydroxyethyl starch (HES) from another source or by omission of HES from the UW formulation. Survival, early and late function, and morphology at the end of a 3-month follow-up period were essentially similar for all three test groups. It is concluded that HES is not required for optimum preservation of the rat liver in this treatment model.

KW - Adenosine

KW - Allopurinol

KW - Animals

KW - Aspartate Aminotransferases

KW - Bilirubin

KW - Glutathione

KW - Hydroxyethyl Starch Derivatives

KW - Insulin

KW - Liver Transplantation

KW - Organ Preservation

KW - Organ Preservation Solutions

KW - Raffinose

KW - Rats

KW - Rats, Inbred Strains

KW - Solutions

KW - Starch

KW - Time Factors

M3 - Article (Academic Journal)

C2 - 1692428

SN - 0041-1337

VL - 49

SP - 869

EP - 872

JO - Transplantation

JF - Transplantation

IS - 5

ER -

Liver preservation with UW solution. I. Evidence that hydroxyethyl starch is not essential

Abstract

Keywords

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