Loading-free supramolecular organic framework drug delivery systems (sof-DDSs) for doxorubicin: normal plasm and multidrug resistant cancer cell-adaptive delivery and release

Chi Yao; Jia Tian; Hui Wang; Dan Wei Zhang; Yi Liu; Fan Zhang; Zhan Ting Li

doi:10.1016/j.cclet.2017.01.005

Loading-free supramolecular organic framework drug delivery systems (sof-DDSs) for doxorubicin: normal plasm and multidrug resistant cancer cell-adaptive delivery and release

Chi Yao, Jia Tian, Hui Wang, Dan Wei Zhang, Yi Liu^*, Fan Zhang, Zhan Ting Li

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

55 Citations (Scopus)

Abstract

Four water-soluble porous supramolecular organic framework drug delivery systems (sof-DDSs) have been used to adsorb doxorubicin (DOX) in water at physiological pH of 7.4, which is driven exclusively by hydrophobicity. The resulting complexes DOX@SOFs are formed instantaneously upon dissolving the components in water. The drug-adsorbed sof-DDSs can undergo plasm circulation with important maintenance of the drug and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells. DOX is released readily in the cancer cells due to the protonation of its amino group in the acidic medium of cancer cells. In vitro and in vivo experiments reveal that the delivery of SOF-a-d remarkably improve the cytotoxicity of DOX for the MCF-7/Adr cells and tumors, leading to 13-19-fold reduction of the IC₅₀ values as compared with that of DOX. This new sof-DDSs strategy omits the indispensable loading process required by most of reported nano-scaled carriers for neutral hydrophobic chemotherapeutic agents, and thus should be highly valuable for future development of low-cost delivery systems.

Original language	English
Pages (from-to)	893-899
Number of pages	7
Journal	Chinese Chemical Letters
Volume	28
Issue number	4
Early online date	9 Jan 2017
DOIs	https://doi.org/10.1016/j.cclet.2017.01.005
Publication status	Published - 1 Apr 2017

Keywords

Controlled release
Doxorubicin
Drug delivery
Human breast cancer
Hydrophobicity
In situ preparation
Supramolecular organic framework

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title = "Loading-free supramolecular organic framework drug delivery systems (sof-DDSs) for doxorubicin: normal plasm and multidrug resistant cancer cell-adaptive delivery and release",

abstract = "Four water-soluble porous supramolecular organic framework drug delivery systems (sof-DDSs) have been used to adsorb doxorubicin (DOX) in water at physiological pH of 7.4, which is driven exclusively by hydrophobicity. The resulting complexes DOX@SOFs are formed instantaneously upon dissolving the components in water. The drug-adsorbed sof-DDSs can undergo plasm circulation with important maintenance of the drug and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells. DOX is released readily in the cancer cells due to the protonation of its amino group in the acidic medium of cancer cells. In vitro and in vivo experiments reveal that the delivery of SOF-a-d remarkably improve the cytotoxicity of DOX for the MCF-7/Adr cells and tumors, leading to 13-19-fold reduction of the IC50 values as compared with that of DOX. This new sof-DDSs strategy omits the indispensable loading process required by most of reported nano-scaled carriers for neutral hydrophobic chemotherapeutic agents, and thus should be highly valuable for future development of low-cost delivery systems.",

keywords = "Controlled release, Doxorubicin, Drug delivery, Human breast cancer, Hydrophobicity, In situ preparation, Supramolecular organic framework",

author = "Chi Yao and Jia Tian and Hui Wang and Zhang, {Dan Wei} and Yi Liu and Fan Zhang and Li, {Zhan Ting}",

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Loading-free supramolecular organic framework drug delivery systems (sof-DDSs) for doxorubicin: normal plasm and multidrug resistant cancer cell-adaptive delivery and release. / Yao, Chi; Tian, Jia; Wang, Hui et al.
In: Chinese Chemical Letters, Vol. 28, No. 4, 01.04.2017, p. 893-899.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Loading-free supramolecular organic framework drug delivery systems (sof-DDSs) for doxorubicin

T2 - normal plasm and multidrug resistant cancer cell-adaptive delivery and release

AU - Yao, Chi

AU - Tian, Jia

AU - Wang, Hui

AU - Zhang, Dan Wei

AU - Liu, Yi

AU - Zhang, Fan

AU - Li, Zhan Ting

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Four water-soluble porous supramolecular organic framework drug delivery systems (sof-DDSs) have been used to adsorb doxorubicin (DOX) in water at physiological pH of 7.4, which is driven exclusively by hydrophobicity. The resulting complexes DOX@SOFs are formed instantaneously upon dissolving the components in water. The drug-adsorbed sof-DDSs can undergo plasm circulation with important maintenance of the drug and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells. DOX is released readily in the cancer cells due to the protonation of its amino group in the acidic medium of cancer cells. In vitro and in vivo experiments reveal that the delivery of SOF-a-d remarkably improve the cytotoxicity of DOX for the MCF-7/Adr cells and tumors, leading to 13-19-fold reduction of the IC50 values as compared with that of DOX. This new sof-DDSs strategy omits the indispensable loading process required by most of reported nano-scaled carriers for neutral hydrophobic chemotherapeutic agents, and thus should be highly valuable for future development of low-cost delivery systems.

AB - Four water-soluble porous supramolecular organic framework drug delivery systems (sof-DDSs) have been used to adsorb doxorubicin (DOX) in water at physiological pH of 7.4, which is driven exclusively by hydrophobicity. The resulting complexes DOX@SOFs are formed instantaneously upon dissolving the components in water. The drug-adsorbed sof-DDSs can undergo plasm circulation with important maintenance of the drug and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells. DOX is released readily in the cancer cells due to the protonation of its amino group in the acidic medium of cancer cells. In vitro and in vivo experiments reveal that the delivery of SOF-a-d remarkably improve the cytotoxicity of DOX for the MCF-7/Adr cells and tumors, leading to 13-19-fold reduction of the IC50 values as compared with that of DOX. This new sof-DDSs strategy omits the indispensable loading process required by most of reported nano-scaled carriers for neutral hydrophobic chemotherapeutic agents, and thus should be highly valuable for future development of low-cost delivery systems.

KW - Controlled release

KW - Doxorubicin

KW - Drug delivery

KW - Human breast cancer

KW - Hydrophobicity

KW - In situ preparation

KW - Supramolecular organic framework

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ER -

Loading-free supramolecular organic framework drug delivery systems (sof-DDSs) for doxorubicin: normal plasm and multidrug resistant cancer cell-adaptive delivery and release

Abstract

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