Loading-free supramolecular organic framework drug delivery systems (sof-DDSs) for doxorubicin: normal plasm and multidrug resistant cancer cell-adaptive delivery and release

Chi Yao, Jia Tian, Hui Wang, Dan Wei Zhang, Yi Liu*, Fan Zhang, Zhan Ting Li

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

33 Citations (Scopus)

Abstract

Four water-soluble porous supramolecular organic framework drug delivery systems (sof-DDSs) have been used to adsorb doxorubicin (DOX) in water at physiological pH of 7.4, which is driven exclusively by hydrophobicity. The resulting complexes DOX@SOFs are formed instantaneously upon dissolving the components in water. The drug-adsorbed sof-DDSs can undergo plasm circulation with important maintenance of the drug and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells. DOX is released readily in the cancer cells due to the protonation of its amino group in the acidic medium of cancer cells. In vitro and in vivo experiments reveal that the delivery of SOF-a-d remarkably improve the cytotoxicity of DOX for the MCF-7/Adr cells and tumors, leading to 13-19-fold reduction of the IC50 values as compared with that of DOX. This new sof-DDSs strategy omits the indispensable loading process required by most of reported nano-scaled carriers for neutral hydrophobic chemotherapeutic agents, and thus should be highly valuable for future development of low-cost delivery systems.

Original languageEnglish
Pages (from-to)893-899
Number of pages7
JournalChinese Chemical Letters
Volume28
Issue number4
Early online date9 Jan 2017
DOIs
Publication statusPublished - 1 Apr 2017

Keywords

  • Controlled release
  • Doxorubicin
  • Drug delivery
  • Human breast cancer
  • Hydrophobicity
  • In situ preparation
  • Supramolecular organic framework

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