Local versus systemic mechanisms underlying supervised exercise training for intermittent claudication

AHR Stewart, FCT Smith, RN Baird, PM Lamont

Research output: Contribution to journalArticle (Academic Journal)peer-review

30 Citations (Scopus)

Abstract

The mechanisms by which exercise training improves intermittent claudication remain unclear. In this article, the effects of local and systemic physiological factors on improved exercise tolerance after a supervised exercise program in claudicants are investigated. A total of 60 patients were randomized to 3 months of supervised exercise followed by 3 months of unsupervised exercise, or to exercise advice alone (control). Supervised exercise increased both pain-free and maximal walking distances. Heart rate during submaximal exercise and resting mean arterial pressure were lower after supervised exercise at 6 months. Serum lactate at maximum claudication increased significantly after 3 months in the supervised exercise group but this change had resolved by 6 months. Symptomatic improvement was accompanied by modest reductions in mean arterial pressure and submaximal heart rate on exercise. Increased serum lactate at maximum claudication subsequently declined despite continued improvement in walking distance, suggesting local adaptations to improve efficiency of muscle oxygen delivery and/or utilization.
Translated title of the contributionLocal versus systemic mechanisms underlying supervised exercise training for intermittent claudication
Original languageEnglish
Pages (from-to)314 - 320
Number of pages7
JournalVascular and Endovascular Surgery
Volume42(4)
DOIs
Publication statusPublished - Aug 2008

Bibliographical note

Publisher: SAGE

Fingerprint Dive into the research topics of 'Local versus systemic mechanisms underlying supervised exercise training for intermittent claudication'. Together they form a unique fingerprint.

Cite this