Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease

Elaine Green, Gareth Elvidge, Nick Jacobsen, Beate Glaser, Ian Jones, Michael C O'Donovan, George Kirov, Michael J Owen, Nick Craddock

Research output: Contribution to journalArticle (Academic Journal)

47 Citations (Scopus)

Abstract

The authors previously reported two families (pedigrees 324 and 5501) in which Darier's disease-a rare, autosomal dominant skin disease-and bipolar disorder cosegregate. In each of these families there is complete cosegregation of mood disorder with a segment of chromosome 12q23-q24, consistent with the existence of a highly penetrant dominant variant. Here molecular genetic analyses aimed at localizing and identifying the susceptibility gene in this region are reported.
Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalAmerican Journal of Psychiatry
Volume162
Issue number1
DOIs
Publication statusPublished - 2005

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