Logic-based Steady-State Analysis and Revision of Metabolic Networks with Inhibition

Oliver Ray, Ken Whelan, Ross King

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

14 Citations (Scopus)

Abstract

This paper presents a qualitative logic-based method for the steady-state analysis and revision of metabolic networks with inhibition. The approach is able to automatically revise an initial metabolic model – through the addition and removal of whole reactions or individual substrates, products and inhibitors – in order to ensure the existence of a steady-state behaviour consistent with a set of experimental observations. We show how this can be done in a nonmonotonic logic programming setting and discuss the challenges that arise when metabolic cycles or mutual inhibitions occur in the underlying network.
Original languageEnglish
Title of host publication2nd International Conference on Complex, Intelligent and Software Intensive Systems (from 3rd International Workshop on Intelligent Informatics in Biology and Medicine)
PublisherIEEE Computer Society
Publication statusPublished - 2010

Bibliographical note

Other page information: 661-666
Conference Proceedings/Title of Journal: 2nd International Conference on Complex, Intelligent and Software Intensive Systems (from 3rd International Workshop on Intelligent Informatics in Biology and Medicine)
Other identifier: 2001157

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    Ray, O., Whelan, K., & King, R. (2010). Logic-based Steady-State Analysis and Revision of Metabolic Networks with Inhibition. In 2nd International Conference on Complex, Intelligent and Software Intensive Systems (from 3rd International Workshop on Intelligent Informatics in Biology and Medicine) IEEE Computer Society. http://www.cs.bris.ac.uk/Publications/pub_master.jsp?id=2001157