Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis

Ahmed Elhakeem, Amy E Taylor, Hazel M Inskip, Jonathan Huang, Toby Mansell, Carina Rodrigues, Federica Asta, Sophia Blaauwendraad, E.Håberg Siri, Jane Halliday, Margreet Harskamp-van Ginkel, Jian-Rong He, Vincent W V Jaddoe, Sharon R Lewin, Gillian Maher, Yannis Manios, Fergus P. McCarthy, Irwin Reiss, Franca Rusconi, Theodosia SalikaMuriel Tafflet, Xiu Qiu, Bjørn O. Åsvold, David Burgner, Jerry Chan, Luigi Gagliardi, Romy Gaillard, Barbara Heude, Maria C Magnus, George Moschonis, Deirdre Murray, Scott M Nelson, Daniela Porta, Richard Saffrey, Henrique Barros, Johan G. Eriksson, Tanja G M Vrijkotte, Deborah A Lawlor

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)


To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age.

Methods and results
Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was
These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART. Longer-term follow-up is warranted to investigate changes over adulthood in the risks of hypertension, dyslipidaemia, and preclinical and clinical cardiovascular disease.
Original languageEnglish
Pages (from-to)1464-1473
Number of pages10
JournalEuropean Heart Journal
Issue number16
Publication statusPublished - 6 Feb 2023

Bibliographical note

Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.


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