Long-term childhood outcomes after interventions for prevention and management of preterm birth

Sarah R Murray, Sarah J Stock, Jane E Norman

Research output: Contribution to journalReview article (Academic Journal)peer-review

Abstract

Globally, preterm birth rates are rising and have a significant impact on neonatal morbidity and mortality. Preterm birth remains difficult to prevent and a number of strategies for preterm birth prevention (progesterone, cervical pessaries, cervical cerclage, tocolytics, and antibiotics) have been identified. While some of these show more promise, there is a paucity of evidence regarding the long-term effects of these strategies on childhood outcomes. Strategies used to improve the health of babies if born preterm, such as antenatal magnesium sulfate for fetal neuroprotection and antenatal corticosteroids for fetal lung maturation, show evidence of short-term benefit but lack large-scale follow-up data of long-term childhood outcomes. Future research on preterm birth interventions should include long-term follow-up of the children, ideally with similar outcome measures to allow for future meta-analyses.

Original languageEnglish
Pages (from-to)519-527
Number of pages9
JournalSeminars in Perinatology
Volume41
Issue number8
DOIs
Publication statusPublished - Dec 2017

Bibliographical note

Copyright © 2017 Elsevier Inc. All rights reserved.

Keywords

  • Administration, Intravaginal
  • Adult
  • Cerclage, Cervical/methods
  • Child
  • Child Development
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Magnesium Sulfate/therapeutic use
  • Patient Outcome Assessment
  • Pessaries
  • Pregnancy
  • Premature Birth/prevention & control
  • Prenatal Care/methods
  • Progesterone/therapeutic use
  • Progestins/therapeutic use
  • Time Factors
  • Tocolytic Agents/therapeutic use

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