Long-term health-related quality of life following surgery for oesophageal cancer

T Djarv, J Lagergren, JM Blazeby, P Lagergren

Research output: Contribution to journalArticle (Academic Journal)peer-review

119 Citations (Scopus)

Abstract

Background: The aim of the study was to assess health-related quality of life (HRQL) in patients with surgically cured oesophageal cancer. Methods: A Swedish nationwide cohort of patients undergoing oesophagectomy for cancer between April 2001 and January 2004 was studied prospectively, and compared with a Swedish age- and sex-adjusted reference population. Validated European Organisation for Research and Treatment of Cancer quality of life questionnaires were used to assess HRQL at 6 months and 3 years after surgery. A mean score difference of 10 or more between groups was considered clinically relevant and tested further for statistical significance. Results: Of 358 patients, 117 (32·7 per cent) survived for at least 3 years. Of these, 87 patients (74·4 per cent) responded to the questionnaires. Six months after surgery, most aspects of HRQL were substantially worse than in the reference population with no improvement at 3 years. Patients alive at 3 years reported significantly poorer role and social function, and significantly more problems with fatigue, diarrhoea, appetite loss, nausea and vomiting, than in the reference population. Conclusion: HRQL in long-term survivors after oesophagectomy does not improve between 6 months and 3 years after surgery, and is worse than that in a comparable reference population. Copyright © 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Translated title of the contributionLong-term health-related quality of life following surgery for oesophageal cancer
Original languageEnglish
Pages (from-to)1121 - 1126
Number of pages6
JournalBritish Journal of Surgery
Volume95(9)
DOIs
Publication statusPublished - Sep 2008

Bibliographical note

Other: Pub med ID 18581441

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