Long-Term Treatment with OnabotulinumtoxinA Results in Consistent, Durable Improvements in Health-Related Quality of Life in Patients with Overactive Bladder

David A. Ginsberg, Marcus J. Drake, Albert Kaufmann, Sidney Radomski, Angelo Gousse, Christopher J. Chermansky, Andrew Magyar, Jean Paul Nicandro, Victor W. Nitti

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)

Abstract

Purpose To present the long-term effects of repeat onabotulinumtoxinA 100U treatment on health-related quality of life in overactive bladder patients with urinary incontinence who had an inadequate response to/were intolerant of an anticholinergic. Materials and Methods Patients completing either of two 24-week, phase III trials could enter a 3-year extension study and request multiple onabotulinumtoxinA 100U treatments as needed. Results for the I-QOL (Incontinence-Quality of Life) and KHQ (King’s Health Questionnaire) are reported for upto 6 treatments. Consistency of response with repeated onabotulinumtoxinA treatments was evaluated by classifying patients by I-QOL response to the first treatment and analyzing responses for treatments 2-6. Results After onabotulinumtoxinA treatments 1-6, improvements in I-QOL scores were consistently 2-3 times the minimally important difference, and improvements in KHQ Role Limitations and Social Limitations domain scores were 5-6 and 3-4 times the minimally important difference. Most patients achieved/exceeded the minimally important difference for I-QOL and KHQ domain scores. Furthermore, 72.9% of patients who achieved/exceeded the minimally important difference for I-QOL after treatment 1 did so in all subsequent treatments. Over one-third (38.3%) of patients with a poor response after treatment 1 achieved improvements greater than the minimally important difference in all subsequent treatments. Conclusions In overactive bladder patients with incontinence, consistent and clinically meaningful improvements in health-related quality of life were observed with repeated onabotulinumtoxinA 100U treatments. A positive response after treatment 1 tended to predict similar responses to subsequent treatments, whereas lack of response to treatment 1 did not preclude positive response(s) to later treatments.
Original languageEnglish
JournalJournal of Urology
Early online date20 May 2017
DOIs
Publication statusE-pub ahead of print - 20 May 2017

Structured keywords

  • Centre for Surgical Research

Keywords

  • urinary bladder
  • overactive
  • urinary incontinence
  • onabotulinumtoxinA
  • botulinum toxin
  • quality of life

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