Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes

Andrew J Simpkin; Chris Metcalfe; Richard M Martin; J Athene Lane; Jenny L Donovan; Freddie C Hamdy; David E Neal; Kate Tilling

doi:10.1177/0962280213503928

Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes

Andrew J Simpkin, Chris Metcalfe, Richard M Martin, J Athene Lane, Jenny L Donovan, Freddie C Hamdy, David E Neal, Kate Tilling

Research output: Contribution to journal › Article (Academic Journal) › peer-review

4 Citations (Scopus)

Abstract

Serial measurements of prostate-specific antigen (PSA) are used as a biomarker for men diagnosed with prostate cancer following an active monitoring programme. Distinguishing pathological changes from natural age-related changes is not straightforward. Here, we compare four approaches to modelling age-related change in PSA with the aim of developing reference ranges for repeated measures of PSA. A suitable model for PSA reference ranges must satisfy two criteria. First, it must offer an accurate description of the trend of PSA on average and in individuals. Second, it must be able to make accurate predictions about new PSA observations for an individual and about the entire PSA trajectory for a new individual.

Original language	English
Journal	Statistical Methods in Medical Research
Early online date	9 Oct 2013
DOIs	https://doi.org/10.1177/0962280213503928
Publication status	Published - 9 Oct 2013

Structured keywords

BTC (Bristol Trials Centre)
Centre for Surgical Research

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10.1177/0962280213503928

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title = "Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes",

abstract = "Serial measurements of prostate-specific antigen (PSA) are used as a biomarker for men diagnosed with prostate cancer following an active monitoring programme. Distinguishing pathological changes from natural age-related changes is not straightforward. Here, we compare four approaches to modelling age-related change in PSA with the aim of developing reference ranges for repeated measures of PSA. A suitable model for PSA reference ranges must satisfy two criteria. First, it must offer an accurate description of the trend of PSA on average and in individuals. Second, it must be able to make accurate predictions about new PSA observations for an individual and about the entire PSA trajectory for a new individual.",

author = "Simpkin, {Andrew J} and Chris Metcalfe and Martin, {Richard M} and Lane, {J Athene} and Donovan, {Jenny L} and Hamdy, {Freddie C} and Neal, {David E} and Kate Tilling",

year = "2013",

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Longitudinal prostate-specific antigen reference ranges : Choosing the underlying model of age-related changes. / Simpkin, Andrew J; Metcalfe, Chris ; Martin, Richard M ; Lane, J Athene ; Donovan, Jenny L; Hamdy, Freddie C; Neal, David E; Tilling, Kate.

In: Statistical Methods in Medical Research, 09.10.2013.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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T1 - Longitudinal prostate-specific antigen reference ranges

T2 - Choosing the underlying model of age-related changes

AU - Simpkin, Andrew J

AU - Metcalfe, Chris

AU - Martin, Richard M

AU - Lane, J Athene

AU - Donovan, Jenny L

AU - Hamdy, Freddie C

AU - Neal, David E

AU - Tilling, Kate

PY - 2013/10/9

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N2 - Serial measurements of prostate-specific antigen (PSA) are used as a biomarker for men diagnosed with prostate cancer following an active monitoring programme. Distinguishing pathological changes from natural age-related changes is not straightforward. Here, we compare four approaches to modelling age-related change in PSA with the aim of developing reference ranges for repeated measures of PSA. A suitable model for PSA reference ranges must satisfy two criteria. First, it must offer an accurate description of the trend of PSA on average and in individuals. Second, it must be able to make accurate predictions about new PSA observations for an individual and about the entire PSA trajectory for a new individual.

AB - Serial measurements of prostate-specific antigen (PSA) are used as a biomarker for men diagnosed with prostate cancer following an active monitoring programme. Distinguishing pathological changes from natural age-related changes is not straightforward. Here, we compare four approaches to modelling age-related change in PSA with the aim of developing reference ranges for repeated measures of PSA. A suitable model for PSA reference ranges must satisfy two criteria. First, it must offer an accurate description of the trend of PSA on average and in individuals. Second, it must be able to make accurate predictions about new PSA observations for an individual and about the entire PSA trajectory for a new individual.

U2 - 10.1177/0962280213503928

DO - 10.1177/0962280213503928

M3 - Article (Academic Journal)

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JO - Statistical Methods in Medical Research

JF - Statistical Methods in Medical Research

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