Longitudinal serological measures of common infection in the Avon Longitudinal Study of Parents and Children cohort

Ruth Mitchell; Hannah Jones; Robert Yolken; Glen Ford; Lorriane Jones-Brando; Susan Ring; Sophie FitzGibbon; George Davey Smith; Nicholas Timpson

doi:10.12688/wellcomeopenres.14565.1

Longitudinal serological measures of common infection in the Avon Longitudinal Study of Parents and Children cohort

Ruth Mitchell, Hannah Jones, Robert Yolken, Glen Ford, Lorriane Jones-Brando, Susan Ring, Sophie FitzGibbon, George Davey Smith, Nicholas Timpson

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Abstract

Antibodies against pathogens provide information on exposure to infectious agents and are meaningful measures of past and present infection. Antibodies were measured in the plasma of children that are the offspring in a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Plasma was collected during clinics at age 5, 7, 11 and 15 years. The antigens examined include: fungal (Saccharomyces cerevisiae); protozoan (Toxoplasma gondii and surface antigen 1 of T. gondii); herpes viruses (cytomegalovirus, Epstein-Barr virus, herpes simplex virus type 1); common colds (influenza virus subtypes H1N1 and H3N2); other antigens (measles); animal (feline herpes virus, Theiler’s virus); bacteria (Helicobacter pylori); dietary antigens (bovine casein alpha protein, bovine casein beta protein). Alongside the depth of data available within the ALSPAC cohort, this longitudinal resource will enable the investigation of the association between infections and a wide variety of outcomes.

Original language	English
Article number	49
Number of pages	8
Journal	Wellcome Open Research
Volume	3
DOIs	https://doi.org/10.12688/wellcomeopenres.14565.1
Publication status	Published - 27 Apr 2018

Keywords

Infection
antibody
ALSPAC

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10.12688/wellcomeopenres.14565.1

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NIHR BRC Mental Health
Gunnell, D. J.
1/04/17 → 31/03/22
Project: Research, Parent

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title = "Longitudinal serological measures of common infection in the Avon Longitudinal Study of Parents and Children cohort",

abstract = "Antibodies against pathogens provide information on exposure to infectious agents and are meaningful measures of past and present infection. Antibodies were measured in the plasma of children that are the offspring in a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Plasma was collected during clinics at age 5, 7, 11 and 15 years. The antigens examined include: fungal (Saccharomyces cerevisiae); protozoan (Toxoplasma gondii and surface antigen 1 of T. gondii); herpes viruses (cytomegalovirus, Epstein-Barr virus, herpes simplex virus type 1); common colds (influenza virus subtypes H1N1 and H3N2); other antigens (measles); animal (feline herpes virus, Theiler{\textquoteright}s virus); bacteria (Helicobacter pylori); dietary antigens (bovine casein alpha protein, bovine casein beta protein). Alongside the depth of data available within the ALSPAC cohort, this longitudinal resource will enable the investigation of the association between infections and a wide variety of outcomes.",

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author = "Ruth Mitchell and Hannah Jones and Robert Yolken and Glen Ford and Lorriane Jones-Brando and Susan Ring and Sophie FitzGibbon and {Davey Smith}, George and Nicholas Timpson",

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T1 - Longitudinal serological measures of common infection in the Avon Longitudinal Study of Parents and Children cohort

AU - Mitchell, Ruth

AU - Jones, Hannah

AU - Yolken, Robert

AU - Ford, Glen

AU - Jones-Brando, Lorriane

AU - Ring, Susan

AU - FitzGibbon, Sophie

AU - Davey Smith, George

AU - Timpson, Nicholas

PY - 2018/4/27

Y1 - 2018/4/27

N2 - Antibodies against pathogens provide information on exposure to infectious agents and are meaningful measures of past and present infection. Antibodies were measured in the plasma of children that are the offspring in a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Plasma was collected during clinics at age 5, 7, 11 and 15 years. The antigens examined include: fungal (Saccharomyces cerevisiae); protozoan (Toxoplasma gondii and surface antigen 1 of T. gondii); herpes viruses (cytomegalovirus, Epstein-Barr virus, herpes simplex virus type 1); common colds (influenza virus subtypes H1N1 and H3N2); other antigens (measles); animal (feline herpes virus, Theiler’s virus); bacteria (Helicobacter pylori); dietary antigens (bovine casein alpha protein, bovine casein beta protein). Alongside the depth of data available within the ALSPAC cohort, this longitudinal resource will enable the investigation of the association between infections and a wide variety of outcomes.

AB - Antibodies against pathogens provide information on exposure to infectious agents and are meaningful measures of past and present infection. Antibodies were measured in the plasma of children that are the offspring in a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Plasma was collected during clinics at age 5, 7, 11 and 15 years. The antigens examined include: fungal (Saccharomyces cerevisiae); protozoan (Toxoplasma gondii and surface antigen 1 of T. gondii); herpes viruses (cytomegalovirus, Epstein-Barr virus, herpes simplex virus type 1); common colds (influenza virus subtypes H1N1 and H3N2); other antigens (measles); animal (feline herpes virus, Theiler’s virus); bacteria (Helicobacter pylori); dietary antigens (bovine casein alpha protein, bovine casein beta protein). Alongside the depth of data available within the ALSPAC cohort, this longitudinal resource will enable the investigation of the association between infections and a wide variety of outcomes.

KW - Infection

KW - antibody

KW - ALSPAC

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DO - 10.12688/wellcomeopenres.14565.1

M3 - Article (Academic Journal)

VL - 3

JO - Wellcome Open Research

JF - Wellcome Open Research

SN - 2398-502X

M1 - 49

ER -

Longitudinal serological measures of common infection in the Avon Longitudinal Study of Parents and Children cohort

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Keywords

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NIHR BRC Mental Health

Cite this