Longitudinal variance components models for systolic blood pressure, fitted using Gibbs sampling

Katrina J Scurrah, Martin D Tobin, Paul R Burton

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)

Abstract

This paper describes an analysis of systolic blood pressure (SBP) in the Genetic Analysis Workshop 13 (GAW13) simulated data. The main aim was to assess evidence for both general and specific genetic effects on the baseline blood pressure and on the rate of change (slope) of blood pressure with time. Generalized linear mixed models were fitted using Gibbs sampling in WinBUGS, and the additive polygenic random effects estimated using these models were then used as continuous phenotypes in a variance components linkage analysis. The first-stage analysis provided evidence for general genetic effects on both the baseline and slope of blood pressure, and the linkage analysis found evidence of several genes, again for both baseline and slope.

Original languageEnglish
Pages (from-to)S25
JournalBMC Genetics
Volume4 Suppl 1
DOIs
Publication statusPublished - 2003

Keywords

  • Adult Children
  • Analysis of Variance
  • Blood Pressure
  • Chromosome Mapping
  • Chromosomes, Human, Pair 21
  • Cohort Studies
  • Female
  • Gene Order
  • Genetic Linkage
  • Humans
  • Longitudinal Studies
  • Male
  • Models, Genetic
  • Models, Statistical
  • Multifactorial Inheritance
  • Pedigree
  • Regression Analysis
  • Sampling Studies
  • Siblings
  • Systole

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