Loss of the normal relationships between growth hormone, growth hormone-binding protein and insulin-like growth factor-I in adolescents with insulin-dependent diabetes mellitus

K L Clayton; J M Holly; L M Carlsson; J Jones; T D Cheetham; A M Taylor; D B Dunger

Loss of the normal relationships between growth hormone, growth hormone-binding protein and insulin-like growth factor-I in adolescents with insulin-dependent diabetes mellitus

K L Clayton, J M Holly, L M Carlsson, J Jones, T D Cheetham, A M Taylor, D B Dunger

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

74 Citations (Scopus)

Abstract

It has been proposed that the dissociation between growth hormone secretion and insulin-like growth factor-I (IGF-I) concentrations in insulin-dependent diabetes mellitus arises because of partial resistance at the GH receptor. In order to explore this hypothesis further we have examined the relations between IGF-I, GH-binding protein (GHBP), and GH secretion in normal subjects and patients with diabetes during puberty.

Original language	English
Pages (from-to)	517-24
Number of pages	8
Journal	Clinical Endocrinology
Volume	41
Issue number	4
Publication status	Published - 1994

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title = "Loss of the normal relationships between growth hormone, growth hormone-binding protein and insulin-like growth factor-I in adolescents with insulin-dependent diabetes mellitus",

abstract = "It has been proposed that the dissociation between growth hormone secretion and insulin-like growth factor-I (IGF-I) concentrations in insulin-dependent diabetes mellitus arises because of partial resistance at the GH receptor. In order to explore this hypothesis further we have examined the relations between IGF-I, GH-binding protein (GHBP), and GH secretion in normal subjects and patients with diabetes during puberty.",

author = "Clayton, {K L} and Holly, {J M} and Carlsson, {L M} and J Jones and Cheetham, {T D} and Taylor, {A M} and Dunger, {D B}",

year = "1994",

language = "English",

volume = "41",

pages = "517--24",

journal = "Clinical Endocrinology",

issn = "0300-0664",

publisher = "Wiley",

number = "4",

}

Loss of the normal relationships between growth hormone, growth hormone-binding protein and insulin-like growth factor-I in adolescents with insulin-dependent diabetes mellitus. / Clayton, K L; Holly, J M; Carlsson, L M; Jones, J; Cheetham, T D; Taylor, A M; Dunger, D B.

In: Clinical Endocrinology, Vol. 41, No. 4, 1994, p. 517-24.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Loss of the normal relationships between growth hormone, growth hormone-binding protein and insulin-like growth factor-I in adolescents with insulin-dependent diabetes mellitus

AU - Clayton, K L

AU - Holly, J M

AU - Carlsson, L M

AU - Jones, J

AU - Cheetham, T D

AU - Taylor, A M

AU - Dunger, D B

PY - 1994

Y1 - 1994

N2 - It has been proposed that the dissociation between growth hormone secretion and insulin-like growth factor-I (IGF-I) concentrations in insulin-dependent diabetes mellitus arises because of partial resistance at the GH receptor. In order to explore this hypothesis further we have examined the relations between IGF-I, GH-binding protein (GHBP), and GH secretion in normal subjects and patients with diabetes during puberty.

AB - It has been proposed that the dissociation between growth hormone secretion and insulin-like growth factor-I (IGF-I) concentrations in insulin-dependent diabetes mellitus arises because of partial resistance at the GH receptor. In order to explore this hypothesis further we have examined the relations between IGF-I, GH-binding protein (GHBP), and GH secretion in normal subjects and patients with diabetes during puberty.

M3 - Article (Academic Journal)

C2 - 7955462

VL - 41

SP - 517

EP - 524

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 4

ER -