Loss of the normal relationships between growth hormone, growth hormone-binding protein and insulin-like growth factor-I in adolescents with insulin-dependent diabetes mellitus

K L Clayton, J M Holly, L M Carlsson, J Jones, T D Cheetham, A M Taylor, D B Dunger

Research output: Contribution to journalArticle (Academic Journal)peer-review

74 Citations (Scopus)

Abstract

It has been proposed that the dissociation between growth hormone secretion and insulin-like growth factor-I (IGF-I) concentrations in insulin-dependent diabetes mellitus arises because of partial resistance at the GH receptor. In order to explore this hypothesis further we have examined the relations between IGF-I, GH-binding protein (GHBP), and GH secretion in normal subjects and patients with diabetes during puberty.
Original languageEnglish
Pages (from-to)517-24
Number of pages8
JournalClinical Endocrinology
Volume41
Issue number4
Publication statusPublished - 1994

Fingerprint Dive into the research topics of 'Loss of the normal relationships between growth hormone, growth hormone-binding protein and insulin-like growth factor-I in adolescents with insulin-dependent diabetes mellitus'. Together they form a unique fingerprint.

Cite this