Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

Qibo Zhang, Linda Bagrade, Jolanta Bernatoniene, Ed Clarke, James C Paton, Tim J Mitchell, Desmond A Nunez, Adam Finn

Research output: Contribution to journalArticle (Academic Journal)peer-review

73 Citations (Scopus)

Abstract

Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection.
Translated title of the contributionLow CD4 T Cell Immunity to Pneumolysin Is Associated with Nasopharyngeal Carriage of Pneumococci in Children
Original languageEnglish
Pages (from-to)1194 - 1202
Number of pages9
JournalJournal of Infectious Diseases
Volume195
Issue number8
DOIs
Publication statusPublished - 15 Apr 2007

Bibliographical note

Publisher: University of Chicago Press

Keywords

  • Tumor Necrosis Factor-alpha
  • Interferon-gamma
  • Streptolysins
  • Humans
  • Child
  • Nasopharynx
  • Cell Proliferation
  • Pneumococcal Infections
  • CD4-Positive T-Lymphocytes
  • Child, Preschool
  • Toll-Like Receptors
  • Streptococcus pneumoniae
  • Bacterial Proteins
  • Cells, Cultured
  • Antibodies, Bacterial
  • Carrier State
  • Time Factors
  • Female
  • Male

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