Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

Qibo Zhang; Linda Bagrade; Jolanta Bernatoniene; Ed Clarke; James C Paton; Tim J Mitchell; Desmond A Nunez; Adam Finn

doi:10.1086/512617

Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

Qibo Zhang, Linda Bagrade, Jolanta Bernatoniene, Ed Clarke, James C Paton, Tim J Mitchell, Desmond A Nunez, Adam Finn

Research output: Contribution to journal › Article (Academic Journal) › peer-review

81 Citations (Scopus)

Abstract

Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection.

Translated title of the contribution	Low CD4 T Cell Immunity to Pneumolysin Is Associated with Nasopharyngeal Carriage of Pneumococci in Children
Original language	English
Pages (from-to)	1194 - 1202
Number of pages	9
Journal	Journal of Infectious Diseases
Volume	195
Issue number	8
DOIs	https://doi.org/10.1086/512617
Publication status	Published - 15 Apr 2007

Bibliographical note

Publisher: University of Chicago Press

Keywords

Tumor Necrosis Factor-alpha
Interferon-gamma
Streptolysins
Humans
Child
Nasopharynx
Cell Proliferation
Pneumococcal Infections
CD4-Positive T-Lymphocytes
Child, Preschool
Toll-Like Receptors
Streptococcus pneumoniae
Bacterial Proteins
Cells, Cultured
Antibodies, Bacterial
Carrier State
Time Factors
Female
Male

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@article{23d257c4deb947d2a340384d903d9d64,

title = "Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children",

abstract = "Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection.",

keywords = "Tumor Necrosis Factor-alpha, Interferon-gamma, Streptolysins, Humans, Child, Nasopharynx, Cell Proliferation, Pneumococcal Infections, CD4-Positive T-Lymphocytes, Child, Preschool, Toll-Like Receptors, Streptococcus pneumoniae, Bacterial Proteins, Cells, Cultured, Antibodies, Bacterial, Carrier State, Time Factors, Female, Male",

author = "Qibo Zhang and Linda Bagrade and Jolanta Bernatoniene and Ed Clarke and Paton, \{James C\} and Mitchell, \{Tim J\} and Nunez, \{Desmond A\} and Adam Finn",

note = "Publisher: University of Chicago Press",

year = "2007",

month = apr,

day = "15",

doi = "10.1086/512617",

language = "English",

volume = "195",

pages = "1194 -- 1202",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

AU - Zhang, Qibo

AU - Bagrade, Linda

AU - Bernatoniene, Jolanta

AU - Clarke, Ed

AU - Paton, James C

AU - Mitchell, Tim J

AU - Nunez, Desmond A

AU - Finn, Adam

N1 - Publisher: University of Chicago Press

PY - 2007/4/15

Y1 - 2007/4/15

N2 - Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection.

AB - Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection.

KW - Tumor Necrosis Factor-alpha

KW - Interferon-gamma

KW - Streptolysins

KW - Humans

KW - Child

KW - Nasopharynx

KW - Cell Proliferation

KW - Pneumococcal Infections

KW - CD4-Positive T-Lymphocytes

KW - Child, Preschool

KW - Toll-Like Receptors

KW - Streptococcus pneumoniae

KW - Bacterial Proteins

KW - Cells, Cultured

KW - Antibodies, Bacterial

KW - Carrier State

KW - Time Factors

KW - Female

KW - Male

U2 - 10.1086/512617

DO - 10.1086/512617

M3 - Article (Academic Journal)

C2 - 17357058

SN - 0022-1899

VL - 195

SP - 1194

EP - 1202

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 8

ER -

Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

Abstract

Bibliographical note

Keywords

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