Low disease activity state in rheumatoid arthritis: Concepts and derivation of minimal disease activity

George Wells*, Maarten Boers, Peter Tugwell, Daniel Aletaha, Jennifer Anderson, Clair Bombardier, Peter Brooks, Maxime Dougados, Paul Emery, David Felson, Jaap Fransen, Dan Furst, Mieke Hazes, Kent Johnson, John Kirwan, Robert Landewé, Marissa Lassere, Kaleb Michaud, Beverley Shea, Maria Suarez-AlmazorAlan Silman, Lee Simon, Josef Smolen, Vibeke Strand, Desiree van der Heijde, Piet van Riel, Fred Wolfe

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

22 Citations (Scopus)

Abstract

With recent advances in therapy, the proportion of patients achieving a satisfactory state of minimal disease activity (MDA) is becoming a more important measure with which to compare different treatment strategies. MDA is between high disease activity and remission and anyone in remission will also be in MDA. This paper summarizes the process of coming to a definition of minimal disease activity in rheumatoid arthritis. Two equivalent preliminary definitions of minimal disease activity for use as secondary outcome measures in clinical trials in RA are proposed: a core-set definition based on the WHO/ILAR core set and a DAS-based definition based on the DAS28.

Original languageEnglish
JournalClinical and Experimental Rheumatology
Volume24
Issue number6 SUPPL. 43
Publication statusPublished - 1 Nov 2006

Keywords

  • Low disease activity state
  • Minimal disease activity
  • Rheumatoid arthritis

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