Low risk for nephrogenic systemic fibrosis in nondialysis patients who have chronic kidney disease and are investigated with gadolinium-enhanced magnetic resonance imaging

Constantina Chrysochou, Albert Power, Aladdin E Shurrab, Sayed Husain, Steven Moser, James Lay, Alan D Salama, Philip A Kalra

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVES: During the past decade, nephrogenic systemic fibrosis (NSF) has been reported in patients who have severe renal impairment and have been exposed to a gadolinium (Gd)-based contrast agent during magnetic resonance imaging (MRI). As a result of positive reporting bias, many suitable patients with chronic kidney disease (CKD) are being denied a highly important form of investigation that can be safely undertaken. We analyzed the safety of Gd-MRI in patients with CKD and varying levels of estimated GFR (eGFR).

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed a retrospective analysis of 2053 unselected patients who had CKD and had received Gd-MRI between 1999 and 2009, so as to determine the risk for NSF related to level of CKD, nature of Gd preparation, and Gd dosage.

RESULTS: Overall, 2053 patients (63.5% men; mean age 60.6 +/- 15.7 years) had 2278 Gd-MRI scans; their mean eGFR was 40.7 +/- 23.7 ml/min. A total of 918 (44.7%) patients had stage 3, 491 (23.9%) had stage 4, and 117 (5.7%) had predialysis stage 5 CKD. No cases of NSF were identified during an average follow-up period of 28.6 +/- 18.2 months.

CONCLUSIONS: In this study, no patients developed NSF during extended follow-up, even after multiple Gd doses in some. Gd-MRI can be safely undertaken in the majority of patients with CKD, but caution is merited for dialysis patients and those with acute kidney injury, with relative caution for predialysis patients with stage 5 CKD.

Original languageEnglish
Pages (from-to)484-9
Number of pages6
JournalClinical Journal of the American Society of Nephrology
Volume5
Issue number3
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Adult
  • Aged
  • Chronic Disease
  • Contrast Media
  • England
  • Female
  • Gadolinium
  • Gadolinium DTPA
  • Glomerular Filtration Rate
  • Humans
  • Kidney Diseases
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging
  • Male
  • Meglumine
  • Middle Aged
  • Nephrogenic Fibrosing Dermopathy
  • Organometallic Compounds
  • Patient Selection
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Severity of Illness Index
  • Time Factors

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