LRP-1 variation is not associated with risk of Alzheimer's disease

Katy A. Chalmers, Rachel Barker, Peter A. Passmore, Francesco Panza, Davide Seripa, Vincenzo Solfrizzi, Seth Love, Jonathan A. Prince, Patrick G. Kehoe

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is characterised by the extensive deposition of amyloid beta (Aβ) within the parenchyma and vasculature of the brain. It is hypothesised that a dysfunction in Aβ degradation and/or its removal from the brain may result in accumulation as plaques. Low density lipoprotein receptor-related protein-1 (LRP-1) is a multifunctional receptor shown to be involved in cholesterol metabolism but also the removal of Aβ from the brain. Its ability to transport Aβ from the brain to the periphery has made it an attractive candidate for involvement in Alzheimer's disease (AD). We have assessed the frequencies of 9 tag- SNPs and the commonly studied synonymous SNP within exon 3 (rs1799986) in a multi-centre AD/control cohort and performed haplotype analysis. We found no evidence from a combined total of 412 controls and 1057 AD patients to support the involvement of LRP-1 variation, including the most commonly studied variant in rs1799986 in conferring genetic susceptibility to increased risk of AD.

Original languageEnglish
Pages (from-to)104-113
Number of pages10
JournalInternational Journal of Molecular Epidemiology
Volume1
Issue number2
Publication statusPublished - 21 Jul 2010

Bibliographical note

Publisher: e-Century Publishing Corporation

Keywords

  • Alzheimer's disease
  • Association analysis
  • LRP-1

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    Chalmers, K. A., Barker, R., Passmore, P. A., Panza, F., Seripa, D., Solfrizzi, V., Love, S., Prince, J. A., & Kehoe, P. G. (2010). LRP-1 variation is not associated with risk of Alzheimer's disease. International Journal of Molecular Epidemiology, 1(2), 104-113.