Lung function in pulmonary hypertension

A. T. Low*, A. R L Medford, A. B. Millar, R. M R Tulloh

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

28 Citations (Scopus)


Breathlessness is a common symptom in pulmonary hypertension (PH) and an important cause of morbidity. Though this has been attributed to the well described pulmonary vascular abnormalities and subsequent cardiac remodelling, changes in the airways of these patients have also been reported and may contribute to symptoms. Our understanding of these airway abnormalities is poor with conflicting findings in many studies. The present review evaluates these studies for the major PH groups. In addition we describe the role of cardiopulmonary exercise testing in the assessment of pulmonary arterial hypertension (PAH) by evaluating cardiopulmonary interaction during exercise. As yet, the reasons for the abnormalities in lung function are unclear, but potential causes and the possible role of inflammation are discussed. Future research is required to provide a better understanding of this to help improve the management of these patients.

Original languageEnglish
Pages (from-to)1244-1249
Number of pages6
JournalRespiratory Medicine
Issue number10
Publication statusPublished - 1 May 2015


  • Congenital heart disease
  • Idiopathic pulmonary arterial hypertension
  • Inflammation
  • Lung function tests
  • Pulmonary arterial hypertension
  • Pulmonary hypertension


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