Lys-gamma3-MSH: a global regulator of hormone sensitive lipase activity?

Katrina A Bicknell, Stephen C Harmer, Stephanie Yiangson, Wendy Lockwood, Andrew B Bicknell

Research output: Contribution to journalReview article (Academic Journal)peer-review

11 Citations (Scopus)


Gamma-melanocyte stimulating hormone (gamma-MSH) is a peptide derived from the ACTH precursor, pro-opiomelanocortin (POMC), and belongs to a family of peptides called the melanocortins that also comprises alpha- and beta-MSH. Although conserved in tetrapods, the biological role of gamma-MSH remains largely undefined. It has been demonstrated previously that gamma-MSH is involved in the regulating the activity of hormone sensitive lipase (HSL) activity in the adrenal and more recently, in the adipocyte. It has been shown also to have effects on the cardiovascular and renal systems. This short review will provide a brief overview of the role of gamma-MSH in the adrenal and the more recent report that it can also regulate HSL function in the adipocyte. We also present some preliminary data purporting a direct role for Lys-gamma(3)-MSH in the regulation of HSL phosphorylation in the heart. Taken together these data suggest that gamma-MSH peptides might play a more widespread role in lipid and cholesterol utilization.

Original languageEnglish
Pages (from-to)71-6
Number of pages6
JournalMolecular and Cellular Endocrinology
Issue number1-2
Publication statusPublished - 5 Mar 2009


  • Adipocytes/metabolism
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins
  • Molecular Sequence Data
  • Peptide Fragments/genetics
  • Perilipin-1
  • Phosphoproteins/metabolism
  • Pro-Opiomelanocortin/genetics
  • Sequence Alignment
  • Sterol Esterase/metabolism


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