Macrophage Activation Syndrome in Children: Diagnosis and Management

Narendra Kumar Bagri; Latika Gupta; Ethan S Sen; A V Ramanan

doi:10.1007/s13312-021-2399-8

Macrophage Activation Syndrome in Children: Diagnosis and Management

Narendra Kumar Bagri^*, Latika Gupta, Ethan S Sen, A V Ramanan

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

11 Citations (Scopus)

Abstract

Macrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality. Early diagnosis and timely initiation of specific therapy is pivotal for a successful outcome. This review outlines the key clinical and laboratory features and management of macrophage activation syndrome.

Original language	English
Pages (from-to)	1155-1161
Number of pages	7
Journal	Indian Pediatrics
Volume	58
Issue number	12
Early online date	26 Mar 2021
DOIs	https://doi.org/10.1007/s13312-021-2399-8
Publication status	Published - 15 Dec 2021

Keywords

Child
Humans
Lymphohistiocytosis, Hemophagocytic/diagnosis
Macrophage Activation Syndrome/diagnosis

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abstract = "Macrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality. Early diagnosis and timely initiation of specific therapy is pivotal for a successful outcome. This review outlines the key clinical and laboratory features and management of macrophage activation syndrome.",

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AU - Bagri, Narendra Kumar

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AU - Sen, Ethan S

AU - Ramanan, A V

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AB - Macrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality. Early diagnosis and timely initiation of specific therapy is pivotal for a successful outcome. This review outlines the key clinical and laboratory features and management of macrophage activation syndrome.

KW - Child

KW - Humans

KW - Lymphohistiocytosis, Hemophagocytic/diagnosis

KW - Macrophage Activation Syndrome/diagnosis

U2 - 10.1007/s13312-021-2399-8

DO - 10.1007/s13312-021-2399-8

M3 - Review article (Academic Journal)

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JO - Indian Pediatrics

JF - Indian Pediatrics

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Macrophage Activation Syndrome in Children: Diagnosis and Management

Abstract

Keywords

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