Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly

Will Wood, Paul Martin

Research output: Contribution to journalArticle (Academic Journal)peer-review

42 Citations (Scopus)
401 Downloads (Pure)

Abstract

Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response.
Original languageEnglish
Pages (from-to)221-233
Number of pages13
JournalDevelopmental Cell
Volume40
Issue number3
DOIs
Publication statusPublished - 6 Feb 2017

Keywords

  • Drosophila
  • macrophage
  • inflammation
  • apoptosis
  • development
  • wound
  • disease
  • migration
  • immunity

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