Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly

Will Wood; Paul Martin

doi:10.1016/j.devcel.2017.01.001

Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly

Will Wood, Paul Martin

Research output: Contribution to journal › Article (Academic Journal) › peer-review

73 Citations (Scopus)

465 Downloads (Pure)

Abstract

Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response.

Original language	English
Pages (from-to)	221-233
Number of pages	13
Journal	Developmental Cell
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2017.01.001
Publication status	Published - 6 Feb 2017

Keywords

Drosophila
macrophage
inflammation
apoptosis
development
wound
disease
migration
immunity

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10.1016/j.devcel.2017.01.001

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This is the final published version of the article (version of record). It first appeared online via Elsevier (Cell Press) at DOI: 10.1016/j.devcel.2017.01.001. Please refer to any applicable terms of use of the publisher.
Final published version, 2.7 MBLicence: CC BY

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Modelling of wound repair and inflammation in the Drosophila embryo
Martin, P. B. (Principal Investigator)
31/12/12 → 30/12/18
Project: Research

Cite this

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abstract = "Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response.",

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N2 - Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response.

AB - Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response.

KW - Drosophila

KW - macrophage

KW - inflammation

KW - apoptosis

KW - development

KW - wound

KW - disease

KW - migration

KW - immunity

U2 - 10.1016/j.devcel.2017.01.001

DO - 10.1016/j.devcel.2017.01.001

M3 - Article (Academic Journal)

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SP - 221

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JO - Developmental Cell

JF - Developmental Cell

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ER -

Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly

Abstract

Keywords

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Projects

Modelling of wound repair and inflammation in the Drosophila embryo

Cite this