Macrophage: SHIP of immunity

Charles D Mills; Anita C Thomas; Laurel L Lenz; Markus Munder

doi:10.3389/978-2-88919-308-5

Macrophage: SHIP of immunity

Charles D Mills, Anita C Thomas, Laurel L Lenz, Markus Munder

Bristol Medical School (THS)

Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

Abstract

Immunology. Why does it exist? Two words. Cure disease. People get diseases. “Test tubes” do not. People fund immunologists for solutions to their health problems. But, immunologists often study leukocytes in test tubes – the laboratory – away from diseases. Why? Because much can be learned from analyzing cellular biochemistry and behaviors in vitro that cannot be ascertained when leukocytes are in animals. At the same time, isolated leukocyte reactions often do not reflect how the immune system operates as a unit. So, it is critical to verify in vitro observations in vivo. Among leukocytes, macrophages are the central initiating and directing element in immune systems, and serve this role through four basic “SHIP” functions in vivo: Sample; Heal; Inhibit; and Present (antigen)

Original language	English
Title of host publication	M1/M2 Macrophages: The Arginine Fork in the Road to Health and Disease
Editors	Charles Mills, Laurel Lenz, Klaus Ley
Place of Publication	USA
Publisher	Frontiers Media S.A.
Pages	42-46
Number of pages	5
ISBN (Electronic)	978-2-88919-499-5
DOIs	https://doi.org/10.3389/978-2-88919-308-5
Publication status	Published - Mar 2015

Keywords

macrophage
innate immunity
M1
M2
wound
cancer
infection
atherosclerosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/978-2-88919-308-5

Handle.net

Persistent link

Cite this

@inbook{73fbd28ee55b4c5aad13e29641132f24,

title = "Macrophage: SHIP of immunity",

abstract = "Immunology. Why does it exist? Two words. Cure disease. People get diseases. “Test tubes” do not. People fund immunologists for solutions to their health problems. But, immunologists often study leukocytes in test tubes – the laboratory – away from diseases. Why? Because much can be learned from analyzing cellular biochemistry and behaviors in vitro that cannot be ascertained when leukocytes are in animals. At the same time, isolated leukocyte reactions often do not reflect how the immune system operates as a unit. So, it is critical to verify in vitro observations in vivo. Among leukocytes, macrophages are the central initiating and directing element in immune systems, and serve this role through four basic “SHIP” functions in vivo: Sample; Heal; Inhibit; and Present (antigen)",

keywords = "macrophage, innate immunity, M1, M2, wound, cancer, infection, atherosclerosis",

author = "Mills, {Charles D} and Thomas, {Anita C} and Lenz, {Laurel L} and Markus Munder",

year = "2015",

month = mar,

doi = "10.3389/978-2-88919-308-5",

language = "English",

pages = "42--46",

editor = "Charles Mills and Laurel Lenz and Klaus Ley",

booktitle = "M1/M2 Macrophages: The Arginine Fork in the Road to Health and Disease",

publisher = "Frontiers Media S.A.",

address = "Switzerland",

}

TY - CHAP

T1 - Macrophage: SHIP of immunity

AU - Mills, Charles D

AU - Thomas, Anita C

AU - Lenz, Laurel L

AU - Munder, Markus

PY - 2015/3

Y1 - 2015/3

N2 - Immunology. Why does it exist? Two words. Cure disease. People get diseases. “Test tubes” do not. People fund immunologists for solutions to their health problems. But, immunologists often study leukocytes in test tubes – the laboratory – away from diseases. Why? Because much can be learned from analyzing cellular biochemistry and behaviors in vitro that cannot be ascertained when leukocytes are in animals. At the same time, isolated leukocyte reactions often do not reflect how the immune system operates as a unit. So, it is critical to verify in vitro observations in vivo. Among leukocytes, macrophages are the central initiating and directing element in immune systems, and serve this role through four basic “SHIP” functions in vivo: Sample; Heal; Inhibit; and Present (antigen)

AB - Immunology. Why does it exist? Two words. Cure disease. People get diseases. “Test tubes” do not. People fund immunologists for solutions to their health problems. But, immunologists often study leukocytes in test tubes – the laboratory – away from diseases. Why? Because much can be learned from analyzing cellular biochemistry and behaviors in vitro that cannot be ascertained when leukocytes are in animals. At the same time, isolated leukocyte reactions often do not reflect how the immune system operates as a unit. So, it is critical to verify in vitro observations in vivo. Among leukocytes, macrophages are the central initiating and directing element in immune systems, and serve this role through four basic “SHIP” functions in vivo: Sample; Heal; Inhibit; and Present (antigen)

KW - macrophage

KW - innate immunity

KW - M1

KW - M2

KW - wound

KW - cancer

KW - infection

KW - atherosclerosis

U2 - 10.3389/978-2-88919-308-5

DO - 10.3389/978-2-88919-308-5

M3 - Chapter in a book

SP - 42

EP - 46

BT - M1/M2 Macrophages: The Arginine Fork in the Road to Health and Disease

A2 - Mills, Charles

A2 - Lenz, Laurel

A2 - Ley, Klaus

PB - Frontiers Media S.A.

CY - USA

ER -

Macrophage: SHIP of immunity

Abstract

Keywords

UN SDGs

Access to Document

Handle.net

Fingerprint

Cite this