Macrophage: SHIP of immunity

Charles D Mills; Anita C Thomas; Laurel L Lenz; Markus Munder

doi:10.3389/978-2-88919-308-5

Macrophage: SHIP of immunity

Charles D Mills
, Anita C Thomas
, Laurel L Lenz
, Markus Munder

Bristol Medical School (THS)

Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

Abstract

Immunology. Why does it exist? Two words. Cure disease. People get diseases. “Test tubes” do not. People fund immunologists for solutions to their health problems. But, immunologists often study leukocytes in test tubes – the laboratory – away from diseases. Why? Because much can be learned from analyzing cellular biochemistry and behaviors in vitro that cannot be ascertained when leukocytes are in animals. At the same time, isolated leukocyte reactions often do not reflect how the immune system operates as a unit. So, it is critical to verify in vitro observations in vivo. Among leukocytes, macrophages are the central initiating and directing element in immune systems, and serve this role through four basic “SHIP” functions in vivo: Sample; Heal; Inhibit; and Present (antigen)

Original language	English
Title of host publication	M1/M2 Macrophages: The Arginine Fork in the Road to Health and Disease
Editors	Charles Mills, Laurel Lenz, Klaus Ley
Place of Publication	USA
Publisher	Frontiers Media S.A.
Pages	42-46
Number of pages	5
ISBN (Electronic)	978-2-88919-499-5
DOIs	https://doi.org/10.3389/978-2-88919-308-5
Publication status	Published - Mar 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

macrophage
innate immunity
M1
M2
wound
cancer
infection
atherosclerosis

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10.3389/978-2-88919-308-5

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KW - wound

KW - cancer

KW - infection

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Macrophage: SHIP of immunity

Abstract

UN SDGs

Keywords

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