Magnetic fields suppress Pseudomonas aeruginosa biofilms and enhance ciprofloxacin activity

H M H N Bandara, D Nguyen, S Mogarala, M Osiñski, H D C Smyth

Research output: Contribution to journalArticle (Academic Journal)peer-review

15 Citations (Scopus)

Abstract

Due to the refractory nature of pathogenic microbial biofilms, innovative biofilm eradication strategies are constantly being sought. Thus, this study addresses a novel approach to eradicate Pseudomonas aeruginosa biofilms. Magnetic nanoparticles (MNP), ciprofloxacin (Cipro), and magnetic fields were systematically evaluated in vitro for their relative anti-biofilm contributions. Twenty-four-hour biofilms exposed to aerosolized MNPs, Cipro, or a combination of both, were assessed in the presence or absence of magnetic fields (Static one-sided, Static switched, Oscillating, Static + oscillating) using changes in bacterial metabolism, biofilm biomass, and biofilm imaging. The biofilms exposed to magnetic fields alone exhibited significant metabolic and biomass reductions (p < 0.05). When biofilms were treated with a MNP/Cipro combination, the most significant metabolic and biomass reductions were observed when exposed to static switched magnetic fields (p < 0.05). The exposure of P. aeruginosa biofilms to a static switched magnetic field alone, or co-administration with MNP/Cipro/MNP + Cipro appears to be a promising approach to eradicate biofilms of this bacterium.

Original languageEnglish
Pages (from-to)443-57
Number of pages15
JournalBiofouling
Volume31
Issue number5
DOIs
Publication statusPublished - 2015

Keywords

  • Anti-Bacterial Agents
  • Biofilms
  • Ciprofloxacin
  • Magnetic Fields
  • Magnetite Nanoparticles
  • Pseudomonas aeruginosa
  • Journal Article

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