Magnetic resonance spectroscopy metabolite profiles predict survival in paediatric brain tumours

Martin Wilson; Carole L Cummins; Lesley Macpherson; Yu Sun; Kal Natarajan; Richard G Grundy; Theodoros N Arvanitis; Risto A Kauppinen; Andrew C Peet

doi:10.1016/j.ejca.2012.09.002

Magnetic resonance spectroscopy metabolite profiles predict survival in paediatric brain tumours

Martin Wilson, Carole L Cummins, Lesley Macpherson, Yu Sun, Kal Natarajan, Richard G Grundy, Theodoros N Arvanitis, Risto A Kauppinen, Andrew C Peet

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Brain tumours cause the highest mortality and morbidity rate of all childhood tumour groups and new methods are required to improve clinical management. (1)H magnetic resonance spectroscopy (MRS) allows non-invasive concentration measurements of small molecules present in tumour tissue, providing clinically useful imaging biomarkers. The primary aim of this study was to investigate whether MRS detectable molecules can predict the survival of paediatric brain tumour patients. PATIENTS AND METHODS: Short echo time (30ms) single voxel (1)H MRS was performed on children attending Birmingham Children's Hospital with a suspected brain tumour and 115 patients were included in the survival analysis. Patients were followed-up for a median period of 35months and Cox-Regression was used to establish the prognostic value of individual MRS detectable molecules. A multivariate model of survival was also investigated to improve prognostic power. RESULTS: Lipids and scyllo-inositol predicted poor survival whilst glutamine and N-acetyl aspartate predicted improved survival (p

Original language	English
Pages (from-to)	457-464
Journal	European Journal of Cancer
Volume	49
Issue number	2
Early online date	1 Oct 2012
DOIs	https://doi.org/10.1016/j.ejca.2012.09.002
Publication status	Published - Jan 2013

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Brain and Behaviour

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title = "Magnetic resonance spectroscopy metabolite profiles predict survival in paediatric brain tumours",

abstract = "Brain tumours cause the highest mortality and morbidity rate of all childhood tumour groups and new methods are required to improve clinical management. (1)H magnetic resonance spectroscopy (MRS) allows non-invasive concentration measurements of small molecules present in tumour tissue, providing clinically useful imaging biomarkers. The primary aim of this study was to investigate whether MRS detectable molecules can predict the survival of paediatric brain tumour patients. PATIENTS AND METHODS: Short echo time (30ms) single voxel (1)H MRS was performed on children attending Birmingham Children's Hospital with a suspected brain tumour and 115 patients were included in the survival analysis. Patients were followed-up for a median period of 35months and Cox-Regression was used to establish the prognostic value of individual MRS detectable molecules. A multivariate model of survival was also investigated to improve prognostic power. RESULTS: Lipids and scyllo-inositol predicted poor survival whilst glutamine and N-acetyl aspartate predicted improved survival (p",

author = "Martin Wilson and Cummins, {Carole L} and Lesley Macpherson and Yu Sun and Kal Natarajan and Grundy, {Richard G} and Arvanitis, {Theodoros N} and Kauppinen, {Risto A} and Peet, {Andrew C}",

year = "2013",

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doi = "10.1016/j.ejca.2012.09.002",

language = "English",

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pages = "457--464",

journal = "European Journal of Cancer",

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publisher = "European School of Oncology (ESO)",

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T1 - Magnetic resonance spectroscopy metabolite profiles predict survival in paediatric brain tumours

AU - Wilson, Martin

AU - Cummins, Carole L

AU - Macpherson, Lesley

AU - Sun, Yu

AU - Natarajan, Kal

AU - Grundy, Richard G

AU - Arvanitis, Theodoros N

AU - Kauppinen, Risto A

AU - Peet, Andrew C

PY - 2013/1

Y1 - 2013/1

N2 - Brain tumours cause the highest mortality and morbidity rate of all childhood tumour groups and new methods are required to improve clinical management. (1)H magnetic resonance spectroscopy (MRS) allows non-invasive concentration measurements of small molecules present in tumour tissue, providing clinically useful imaging biomarkers. The primary aim of this study was to investigate whether MRS detectable molecules can predict the survival of paediatric brain tumour patients. PATIENTS AND METHODS: Short echo time (30ms) single voxel (1)H MRS was performed on children attending Birmingham Children's Hospital with a suspected brain tumour and 115 patients were included in the survival analysis. Patients were followed-up for a median period of 35months and Cox-Regression was used to establish the prognostic value of individual MRS detectable molecules. A multivariate model of survival was also investigated to improve prognostic power. RESULTS: Lipids and scyllo-inositol predicted poor survival whilst glutamine and N-acetyl aspartate predicted improved survival (p

AB - Brain tumours cause the highest mortality and morbidity rate of all childhood tumour groups and new methods are required to improve clinical management. (1)H magnetic resonance spectroscopy (MRS) allows non-invasive concentration measurements of small molecules present in tumour tissue, providing clinically useful imaging biomarkers. The primary aim of this study was to investigate whether MRS detectable molecules can predict the survival of paediatric brain tumour patients. PATIENTS AND METHODS: Short echo time (30ms) single voxel (1)H MRS was performed on children attending Birmingham Children's Hospital with a suspected brain tumour and 115 patients were included in the survival analysis. Patients were followed-up for a median period of 35months and Cox-Regression was used to establish the prognostic value of individual MRS detectable molecules. A multivariate model of survival was also investigated to improve prognostic power. RESULTS: Lipids and scyllo-inositol predicted poor survival whilst glutamine and N-acetyl aspartate predicted improved survival (p

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DO - 10.1016/j.ejca.2012.09.002

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SN - 0014-2964

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SP - 457

EP - 464

JO - European Journal of Cancer

JF - European Journal of Cancer

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Magnetic resonance spectroscopy metabolite profiles predict survival in paediatric brain tumours

Abstract

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