Making fair comparisons in pregnancy medication safety studies: an overview of advanced methods for confounding control

Mollie E. Wood*, Kate L. Lapane, Marleen M.H.J. van Gelder, Dheeraj Rai, Hedvig M.E. Nordeng

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

15 Citations (Scopus)
228 Downloads (Pure)

Abstract

Understanding the safety of medication use during pregnancy relies on observational studies: However, confounding in observational studies poses a threat to the validity of estimates obtained from observational data. Newer methods, such as marginal structural models and propensity calibration, have emerged to deal with complex confounding problems, but these methods have seen limited uptake in the pregnancy medication literature. In this article, we provide an overview of newer advanced methods for confounding control and show how these methods are relevant for pregnancy medication safety studies.

Original languageEnglish
Pages (from-to)140-147
Number of pages8
JournalPharmacoepidemiology and Drug Safety
Volume27
Issue number2
Early online date17 Oct 2017
DOIs
Publication statusPublished - 1 Feb 2018

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