Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails

Katherine Williams, Agnieszka J Szwalbe, Kate M J de Mattos-Shipley, Andrew M. Bailey, Russell Cox, Chris L Willis

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Maleidrides are a family of polyketide-based dimeric natural products isolated from fungi. Many maleidrides possess significant bioactivities, making them attractive pharmaceutical or agrochemical lead compounds. Their unusual biosynthetic pathways have fascinated scientists for decades, with recent advances in our bioinformatic and enzymatic understanding providing further insights into their construction. However, many intriguing questions remain, including exactly how the enzymatic dimerisation, which creates the diverse core structure of the maleidrides, is controlled. This review will explore the literature from the initial isolation of maleidride compounds in the 1930s, through the first full structural elucidation in the 1960s, to the most recent in vivo, in vitro, and in silico analyses.
Original languageEnglish
Pages (from-to)128-157
JournalNatural Product Reports
Volume40
DOIs
Publication statusPublished - 21 Sept 2022

Bibliographical note

Funding Information:
We would like to thank the MRC for funding KW and KMJdMS (MR/N029909/1), and the BBSRC and Syngenta for funding AJS (BB/J006289/1). We would like to thank Dr Claudio Greco for useful discussions on this work.

Publisher Copyright:
© 2022 The Royal Society of Chemistry.

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