Mammary analogue secretory carcinoma of the salivary glands: a diagnostic dilemma

N. Hindocha, M.H. Wilson, M. Pring, C.W. Hughes, S.J. Thomas

Research output: Contribution to journalArticle (Academic Journal)peer-review

17 Citations (Scopus)
350 Downloads (Pure)


Mammary analogue secretory carcinoma (MASC) is a recently identified salivary gland neoplasm that can mimic other salivary gland tumours such as acinic cell carcinoma and cystadenocarcinoma. It is distinguished from these by differences in immunohistochemical profile and the identification of an ETV6-NTRK3 translocation (12;15)(p13;q25), which is also found in secretory carcinomas of the breast. Previous publications have suggested that MASC tumours have similar biological behaviour to acinic cell carcinoma. We report two cases of MASC that affected the upper lip, and showed an infiltrative and locally aggressive growth pattern that required several operations to ensure clearance of microscopic tumour cells.

Original languageEnglish
Pages (from-to)290-292
Number of pages3
JournalBritish Journal of Oral and Maxillofacial Surgery
Issue number3
Early online date12 Aug 2016
Publication statusPublished - 1 Apr 2017


  • Mammary analogue secretory carcinoma
  • MASC
  • salivary gland malignancy
  • minor salivary gland
  • lip
  • ETV6-NTRK3 translocation


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