Mammary analogue secretory carcinoma of the salivary glands: a diagnostic dilemma

N. Hindocha; M.H. Wilson; M. Pring; C.W. Hughes; S.J. Thomas

doi:10.1016/j.bjoms.2016.07.029

Mammary analogue secretory carcinoma of the salivary glands: a diagnostic dilemma

N. Hindocha, M.H. Wilson, M. Pring, C.W. Hughes, S.J. Thomas

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Abstract

Mammary analogue secretory carcinoma (MASC) is a recently identified salivary gland neoplasm that can mimic other salivary gland tumours such as acinic cell carcinoma and cystadenocarcinoma. It is distinguished from these by differences in immunohistochemical profile and the identification of an ETV6-NTRK3 translocation (12;15)(p13;q25), which is also found in secretory carcinomas of the breast. Previous publications have suggested that MASC tumours have similar biological behaviour to acinic cell carcinoma. We report two cases of MASC that affected the upper lip, and showed an infiltrative and locally aggressive growth pattern that required several operations to ensure clearance of microscopic tumour cells.

Original language	English
Pages (from-to)	290-292
Number of pages	3
Journal	British Journal of Oral and Maxillofacial Surgery
Volume	55
Issue number	3
Early online date	12 Aug 2016
DOIs	https://doi.org/10.1016/j.bjoms.2016.07.029
Publication status	Published - 1 Apr 2017

Keywords

Mammary analogue secretory carcinoma
MASC
salivary gland malignancy
minor salivary gland
lip
ETV6-NTRK3 translocation

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10.1016/j.bjoms.2016.07.029

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at http://www.sciencedirect.com/science/article/pii/S0266435616302200. Please refer to any applicable terms of use of the publisher.
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title = "Mammary analogue secretory carcinoma of the salivary glands: a diagnostic dilemma",

abstract = "Mammary analogue secretory carcinoma (MASC) is a recently identified salivary gland neoplasm that can mimic other salivary gland tumours such as acinic cell carcinoma and cystadenocarcinoma. It is distinguished from these by differences in immunohistochemical profile and the identification of an ETV6-NTRK3 translocation (12;15)(p13;q25), which is also found in secretory carcinomas of the breast. Previous publications have suggested that MASC tumours have similar biological behaviour to acinic cell carcinoma. We report two cases of MASC that affected the upper lip, and showed an infiltrative and locally aggressive growth pattern that required several operations to ensure clearance of microscopic tumour cells.",

keywords = "Mammary analogue secretory carcinoma, MASC, salivary gland malignancy, minor salivary gland, lip, ETV6-NTRK3 translocation",

author = "N. Hindocha and M.H. Wilson and M. Pring and C.W. Hughes and S.J. Thomas",

year = "2017",

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doi = "10.1016/j.bjoms.2016.07.029",

language = "English",

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TY - JOUR

T1 - Mammary analogue secretory carcinoma of the salivary glands

T2 - a diagnostic dilemma

AU - Hindocha, N.

AU - Wilson, M.H.

AU - Pring, M.

AU - Hughes, C.W.

AU - Thomas, S.J.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Mammary analogue secretory carcinoma (MASC) is a recently identified salivary gland neoplasm that can mimic other salivary gland tumours such as acinic cell carcinoma and cystadenocarcinoma. It is distinguished from these by differences in immunohistochemical profile and the identification of an ETV6-NTRK3 translocation (12;15)(p13;q25), which is also found in secretory carcinomas of the breast. Previous publications have suggested that MASC tumours have similar biological behaviour to acinic cell carcinoma. We report two cases of MASC that affected the upper lip, and showed an infiltrative and locally aggressive growth pattern that required several operations to ensure clearance of microscopic tumour cells.

AB - Mammary analogue secretory carcinoma (MASC) is a recently identified salivary gland neoplasm that can mimic other salivary gland tumours such as acinic cell carcinoma and cystadenocarcinoma. It is distinguished from these by differences in immunohistochemical profile and the identification of an ETV6-NTRK3 translocation (12;15)(p13;q25), which is also found in secretory carcinomas of the breast. Previous publications have suggested that MASC tumours have similar biological behaviour to acinic cell carcinoma. We report two cases of MASC that affected the upper lip, and showed an infiltrative and locally aggressive growth pattern that required several operations to ensure clearance of microscopic tumour cells.

KW - Mammary analogue secretory carcinoma

KW - MASC

KW - salivary gland malignancy

KW - minor salivary gland

KW - lip

KW - ETV6-NTRK3 translocation

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U2 - 10.1016/j.bjoms.2016.07.029

DO - 10.1016/j.bjoms.2016.07.029

M3 - Article (Academic Journal)

C2 - 27527989

VL - 55

SP - 290

EP - 292

JO - British Journal of Oral and Maxillofacial Surgery

JF - British Journal of Oral and Maxillofacial Surgery

SN - 0266-4356

IS - 3

ER -

Mammary analogue secretory carcinoma of the salivary glands: a diagnostic dilemma

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Dr Miranda Pring

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Mammary analogue secretory carcinoma of the salivary glands: a diagnostic dilemma

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Dr Miranda Pring

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