Mammary analogue secretory carcinoma (MASC) is a recently identified salivary gland neoplasm that can mimic other salivary gland tumours such as acinic cell carcinoma and cystadenocarcinoma. It is distinguished from these by differences in immunohistochemical profile and the identification of an ETV6-NTRK3 translocation (12;15)(p13;q25), which is also found in secretory carcinomas of the breast. Previous publications have suggested that MASC tumours have similar biological behaviour to acinic cell carcinoma. We report two cases of MASC that affected the upper lip, and showed an infiltrative and locally aggressive growth pattern that required several operations to ensure clearance of microscopic tumour cells.
|Number of pages||3|
|Journal||British Journal of Oral and Maxillofacial Surgery|
|Early online date||12 Aug 2016|
|Publication status||Published - 1 Apr 2017|
- Mammary analogue secretory carcinoma
- salivary gland malignancy
- minor salivary gland
- ETV6-NTRK3 translocation
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Dr Miranda Pring
- Bristol Dental School - Consultant Senior Lecturer in Oral Maxillofacial Pathology