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Managing hypoxic ischaemic encephalopathy in term newborn infant

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalPaediatrics and Child Health
Issue number9
Early online date27 Jul 2018
DateAccepted/In press - 3 Jul 2018
DateE-pub ahead of print - 27 Jul 2018
DatePublished (current) - 1 Sep 2018


Hypoxic–ischaemic encephalopathy (HIE) is a brain dysfunction resulting from inadequate blood flow and oxygenation to the whole body during the perinatal period. It is a major cause of brain injury and is associated with mortality and significant disabilities in later life. Following HIE acute, secondary and tertiary phases of brain injury lasting from hours to years occurs. Therapeutic hypothermia reduces death and improves the neurodevelopment in infants with moderate to severe HIE. Passive cooling can be initiated soon after birth in infants that fulfil criteria for the treatment. Active cooling with appropriate intensive and supportive care including respiratory and cardiovascular support, maintaining normoglycaemia, sedation, and seizure management is essential for minimising the brain injury. In cooled infants likely to have a worse prognosis re-orientation of care is often considered in the infant's best interests. This short review aims to explain the underlying pathophysiological effects of HIE and its management.

    Research areas

  • aetiology/therapeutic, cooling, hypothermia, hypoxia-ischaemia, neonatal encephalopathy

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    Rights statement: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 139 KB, PDF document

    Licence: CC BY-NC-ND


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