Manganese(I)-Catalyzed C−H Activation: The Key Role of a 7-Membered Manganacycle in H-Transfer and Reductive Elimination

Nasiru P. Yahaya, Kate M. Appleby, Magdalene Teh, Conrad Wagner, Erik Troschke, Joshua T W Bray, Simon B. Duckett, L. Anders Hammarback, Jonathan S. Ward, Jessica Milani, Natalie E. Pridmore, Adrian C. Whitwood, Jason M. Lynam*, Ian J S Fairlamb

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

65 Citations (Scopus)

Abstract

Manganese-catalyzed C−H bond activation chemistry is emerging as a powerful and complementary method for molecular functionalization. A highly reactive seven-membered MnIintermediate is detected and characterized that is effective for H-transfer or reductive elimination to deliver alkenylated or pyridinium products, respectively. The two pathways are determined at MnIby judicious choice of an electron-deficient 2-pyrone substrate containing a 2-pyridyl directing group, which undergoes regioselective C−H bond activation, serving as a valuable system for probing the mechanistic features of Mn C−H bond activation chemistry.

Original languageEnglish
Pages (from-to)12455-12459
Number of pages5
JournalAngewandte Chemie - International Edition
Volume55
Issue number40
DOIs
Publication statusPublished - 2016

Keywords

  • catalysis
  • C−H activation
  • functionalization
  • manganese
  • sustainability

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