Manipulating the diastereoselectivity of ortholithiation in planar chiral ferrocenes

Simon A. Herbert, Dominic C. Castell, Jonathan Clayden, Gareth E. Arnott*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

22 Citations (Scopus)

Abstract

The sense of asymmetric ortholithiation directed by a chiral oxazoline may be inverted simply by the choice of achiral ligand. Comparison of results with a number of ferrocenyl oxazoline derivatives suggests that lithiation takes place by coordination to the oxazoline nitrogen irrespective of the ligand used.

Original languageEnglish
Pages (from-to)3334-3337
Number of pages4
JournalOrganic Letters
Volume15
Issue number13
Early online date25 Jun 2013
DOIs
Publication statusPublished - 5 Jul 2013

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