Mapping associations of polygenic scores with autistic and ADHD traits in a single city region

Zoe E Reed; Richard G Thomas; Andrew W Boyd; Gareth J Griffith; Tim Morris; Dheeraj Rai; David J Manley; George Davey Smith; Oliver S.P. Davis

doi:10.1111/jcpp.14047

Mapping associations of polygenic scores with autistic and ADHD traits in a single city region

Zoe E Reed^*, Richard G Thomas, Andrew W Boyd, Gareth J Griffith, Tim Morris, Dheeraj Rai, David J Manley, George Davey Smith, Oliver S.P. Davis

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

Background: The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants?

Methods: We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N=4,255 to 6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.

Results: Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences.

Conclusions: These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.

Original language	English
Number of pages	12
Journal	Journal of Child Psychology and Psychiatry
Early online date	14 Aug 2024
DOIs	https://doi.org/10.1111/jcpp.14047
Publication status	E-pub ahead of print - 14 Aug 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.

Research Groups and Themes

ALSPAC
bristol population
Bristol Population Health Science Institute

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10.1111/jcpp.14047Licence: CC BY

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Cite this

@article{002a53f5ce354cf8898028c4e9d98669,

title = "Mapping associations of polygenic scores with autistic and ADHD traits in a single city region",

abstract = "Background: The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants?Methods: We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N=4,255 to 6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.Results: Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences.Conclusions: These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.",

author = "Reed, {Zoe E} and Thomas, {Richard G} and Boyd, {Andrew W} and Griffith, {Gareth J} and Tim Morris and Dheeraj Rai and Manley, {David J} and {Davey Smith}, George and Davis, {Oliver S.P.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.",

year = "2024",

month = aug,

day = "14",

doi = "10.1111/jcpp.14047",

language = "English",

journal = "Journal of Child Psychology and Psychiatry",

issn = "0021-9630",

publisher = "Wiley",

}

TY - JOUR

T1 - Mapping associations of polygenic scores with autistic and ADHD traits in a single city region

AU - Reed, Zoe E

AU - Thomas, Richard G

AU - Boyd, Andrew W

AU - Griffith, Gareth J

AU - Morris, Tim

AU - Rai, Dheeraj

AU - Manley, David J

AU - Davey Smith, George

AU - Davis, Oliver S.P.

PY - 2024/8/14

Y1 - 2024/8/14

N2 - Background: The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants?Methods: We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N=4,255 to 6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.Results: Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences.Conclusions: These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.

AB - Background: The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants?Methods: We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N=4,255 to 6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.Results: Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences.Conclusions: These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.

U2 - 10.1111/jcpp.14047

DO - 10.1111/jcpp.14047

M3 - Article (Academic Journal)

C2 - 39143033

SN - 0021-9630

JO - Journal of Child Psychology and Psychiatry

JF - Journal of Child Psychology and Psychiatry

ER -

Mapping associations of polygenic scores with autistic and ADHD traits in a single city region

Abstract

Bibliographical note

Research Groups and Themes

Access to Document

Handle.net

Fingerprint

Projects

Integrative Epidemiology Unit

Equipment

HPC (High Performance Computing) and HTC (High Throughput Computing) Facilities

Research Data Storage Facility (RDSF)

Cite this