Abstract

Background: The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants?

Methods: We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N=4,255 to 6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.

Results: Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences.

Conclusions: These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.
Original languageEnglish
Number of pages12
JournalJournal of Child Psychology and Psychiatry
Early online date14 Aug 2024
DOIs
Publication statusE-pub ahead of print - 14 Aug 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.

Research Groups and Themes

  • ALSPAC
  • bristol population
  • Bristol Population Health Science Institute

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  • Integrative Epidemiology Unit

    Davey Smith, G. (Principal Investigator)

    1/04/2331/03/28

    Project: Research

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