Mapping Structure–Function Relationships within Cerebellar Circuits

Richard Apps; Charlotte L Lawrenson; Elena Paci; Nadia L Cerminara

doi:10.1007/978-1-0716-2026-7_4

Mapping Structure–Function Relationships within Cerebellar Circuits

Richard Apps^*, Charlotte L Lawrenson, Elena Paci, Nadia L Cerminara^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

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Abstract

A key organizational feature of the cerebellum is its division into a series of cerebellar modules. The cortical component of each module is termed a zone. Each zone is defined by its climbing input originating from a well-defined region of the inferior olive, which targets one or more longitudinal zones of Purkinje cells within the cerebellar cortex. In turn, Purkinje cells within each zone project to specific regions of the cerebellar and vestibular nuclei. The behavioral significance of zones remains poorly understood.

This chapter will describe approaches to physiologically and anatomically identify cerebellar cortical zones in both acute and chronic preparations (rat and cat) as well as methods to record from zones during behavior in order to determine the role that they have in cerebellar function.

Original language	English
Title of host publication	Neuromethods
Subtitle of host publication	Measuring Cerebellar Function
Editors	Roy V. Sillitoe
Publisher	Humana Press
Pages	69-90
Number of pages	22
Volume	177
ISBN (Electronic)	978-1-0716-2026-7
ISBN (Print)	978-1-0716-2025-0
DOIs	https://doi.org/10.1007/978-1-0716-2026-7_4
Publication status	Published - 1 Jan 2022

Publication series

Name	Neuromethods
Volume	177
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

Bibliographical note

Funding Information:
This work was supported by the Centre National pour la Recherche Scientifique (CNRS), Strasbourg University, the Agence Nationale pour la Recherche (ANR-2015-CeMod, ANR-2019-MultiMod, ANR-2019-NetOnTime) and by the Fondation pour la Recherche Medicale to PI (# DEQ20140329514) and LS.

Publisher Copyright:
© 2022, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Cerebellar zones
Cerebellar modules
Inferior olive
Cerebellar nuclei
Rat
Cat
Tract tracing
Retrograde
Anterograde
Electrophysiology

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10.1007/978-1-0716-2026-7_4

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title = "Mapping Structure–Function Relationships within Cerebellar Circuits",

abstract = "A key organizational feature of the cerebellum is its division into a series of cerebellar modules. The cortical component of each module is termed a zone. Each zone is defined by its climbing input originating from a well-defined region of the inferior olive, which targets one or more longitudinal zones of Purkinje cells within the cerebellar cortex. In turn, Purkinje cells within each zone project to specific regions of the cerebellar and vestibular nuclei. The behavioral significance of zones remains poorly understood.This chapter will describe approaches to physiologically and anatomically identify cerebellar cortical zones in both acute and chronic preparations (rat and cat) as well as methods to record from zones during behavior in order to determine the role that they have in cerebellar function.",

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KW - Cerebellar nuclei

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KW - Cat

KW - Tract tracing

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KW - Anterograde

KW - Electrophysiology

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T3 - Neuromethods

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BT - Neuromethods

A2 - Sillitoe, Roy V.

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Mapping Structure–Function Relationships within Cerebellar Circuits

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