Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

Laura Schellhas; Giulietta S Monasso; Janine F Felix; Vincent Wv Jaddoe; Peiyuan Huang; Sílvia Fernández-Barrés; Martine Vrijheid; Giancarlo Pesce; Isabella Annesi-Maesano; Christian M Page; Anne-Lise Brantsæter; Mona Bekkhus; Siri E Håberg; Stephanie J London; Marcus R Munafò; Luisa Zuccolo; Gemma C Sharp

doi:10.2217/epi-2023-0263

Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

Laura Schellhas^*, Giulietta S Monasso, Janine F Felix, Vincent Wv Jaddoe, Peiyuan Huang, Sílvia Fernández-Barrés, Martine Vrijheid, Giancarlo Pesce, Isabella Annesi-Maesano, Christian M Page, Anne-Lise Brantsæter, Mona Bekkhus, Siri E Håberg, Stephanie J London, Marcus R Munafò, Luisa Zuccolo, Gemma C Sharp

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

1 Citation (Scopus)

Abstract

Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.

Original language	English
Pages (from-to)	1179-1193
Number of pages	15
Journal	Epigenomics
Volume	15
Issue number	22
DOIs	https://doi.org/10.2217/epi-2023-0263
Publication status	Published - 29 Nov 2023

Research Groups and Themes

TARG

Keywords

Pregnancy
Female
Humans
Caffeine/adverse effects
DNA Methylation
Epigenome
Fetal Blood
Homeodomain Proteins

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Sharp, G. C. (Principal Investigator) & Johnson, L. (Co-Investigator)
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Schellhas, L., Monasso, G. S., Felix, J. F., Jaddoe, V. W., Huang, P., Fernández-Barrés, S., Vrijheid, M., Pesce, G., Annesi-Maesano, I., Page, C. M., Brantsæter, A.-L., Bekkhus, M., Håberg, S. E., London, S. J., Munafò, M. R., Zuccolo, L., & Sharp, G. C. (2023). Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis. Epigenomics, 15(22), 1179-1193. https://doi.org/10.2217/epi-2023-0263

@article{591a37c1c110405abd74d2558b7d9ab0,

title = "Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis",

abstract = " Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials \& methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings. ",

keywords = "Pregnancy, Female, Humans, Caffeine/adverse effects, DNA Methylation, Epigenome, Fetal Blood, Homeodomain Proteins",

author = "Laura Schellhas and Monasso, \{Giulietta S\} and Felix, \{Janine F\} and Jaddoe, \{Vincent Wv\} and Peiyuan Huang and S{\'i}lvia Fern{\'a}ndez-Barr{\'e}s and Martine Vrijheid and Giancarlo Pesce and Isabella Annesi-Maesano and Page, \{Christian M\} and Anne-Lise Brants{\ae}ter and Mona Bekkhus and H{\aa}berg, \{Siri E\} and London, \{Stephanie J\} and Munaf{\`o}, \{Marcus R\} and Luisa Zuccolo and Sharp, \{Gemma C\}",

year = "2023",

month = nov,

day = "29",

doi = "10.2217/epi-2023-0263",

language = "English",

volume = "15",

pages = "1179--1193",

journal = "Epigenomics",

issn = "1750-1911",

publisher = "Taylor \& Francis Group",

number = "22",

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Schellhas, L, Monasso, GS, Felix, JF, Jaddoe, VW, Huang, P, Fernández-Barrés, S, Vrijheid, M, Pesce, G, Annesi-Maesano, I, Page, CM, Brantsæter, A-L, Bekkhus, M, Håberg, SE, London, SJ, Munafò, MR, Zuccolo, L & Sharp, GC 2023, 'Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis', Epigenomics, vol. 15, no. 22, pp. 1179-1193. https://doi.org/10.2217/epi-2023-0263

TY - JOUR

T1 - Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation

T2 - an epigenome-wide association study meta-analysis

AU - Schellhas, Laura

AU - Monasso, Giulietta S

AU - Felix, Janine F

AU - Jaddoe, Vincent Wv

AU - Huang, Peiyuan

AU - Fernández-Barrés, Sílvia

AU - Vrijheid, Martine

AU - Pesce, Giancarlo

AU - Annesi-Maesano, Isabella

AU - Page, Christian M

AU - Brantsæter, Anne-Lise

AU - Bekkhus, Mona

AU - Håberg, Siri E

AU - London, Stephanie J

AU - Munafò, Marcus R

AU - Zuccolo, Luisa

AU - Sharp, Gemma C

PY - 2023/11/29

Y1 - 2023/11/29

N2 - Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.

AB - Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.

KW - Pregnancy

KW - Female

KW - Humans

KW - Caffeine/adverse effects

KW - DNA Methylation

KW - Epigenome

KW - Fetal Blood

KW - Homeodomain Proteins

U2 - 10.2217/epi-2023-0263

DO - 10.2217/epi-2023-0263

M3 - Review article (Academic Journal)

C2 - 38018434

SN - 1750-1911

VL - 15

SP - 1179

EP - 1193

JO - Epigenomics

JF - Epigenomics

IS - 22

ER -

Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

Abstract

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