Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families

Abigail Fraser*, Catarina Almqvist, Henrik Larsson, Niklas Langstrom, Debbie A. Lawlor

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

24 Citations (Scopus)

Abstract

Aims/hypothesis The aim of this study was to investigate the association between maternal diabetes in pregnancy and offspring cognitive ability and also to assess whether the association was due to intrauterine mechanisms or shared familial characteristics.

Methods We linked national registers and conducted a prospective cohort study of singleton Swedish-born men to explore associations between maternal pregnancy diabetes and educational achievement at age 16 years, the age of completing compulsory education in Sweden (n = 391,545 men from 337,174 families, graduating in 1988-1997 and n = 326,033 men from 282,079 families, graduating in 1998-2009), and intelligence quotient (IQ) at the mandatory conscription examination at 18 years of age (n = 664,871 from 543,203 families).

Results Among non-siblings, maternal diabetes in pregnancy was associated with lower offspring cognitive ability even after adjustment for maternal age at birth, parity, education, early-pregnancy BMI, offspring birth year, gestational age and birthweight. For example, in non-siblings, the IQ of men whose mothers had diabetes in their pregnancy was on average 1.36 points lower (95% CI -2.12, -0.60) than men whose mothers did not have diabetes. In comparison, we found no such association within sibships (mean difference 1.70; 95% CI -1.80, 5.21).

Conclusions/interpretation The association between maternal diabetes in pregnancy and offspring cognitive outcomes is likely explained by shared familial characteristics and not by an intrauterine mechanism.

Original languageEnglish
Pages (from-to)102-109
Number of pages8
JournalDiabetologia
Volume57
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Cognition
  • Diabetes
  • IQ
  • Pregnancy
  • Sibling comparison
  • Swedish registers
  • POPULATION-BASED COHORT
  • MOTHERS
  • CHILDREN
  • OUTCOMES
  • WOMEN
  • AGE
  • ASSOCIATIONS
  • METAANALYSIS
  • PREPREGNANCY
  • MELLITUS

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