Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study

Berit Skretting Solberg; Liv Grimstvedt Kvalvik; Johanne Telnes Instanes; Catharina A. Hartman; Kari Klungsøyr; Lin Li; Henrik Larsson; Per M Magnus; Pål Rasmus Njølstad; Stefan Johansson; Ole A. Andreassen; Nora Refsum Bakken; Mona Bekkhus; Chloe Austerberry; Dinka Smajlagic; Alexandra Havdahl; Elizabeth C. Corfield; Jan Haavik; Rolf Gjestad; Tetyana Zayats

doi:10.1016/j.biopsych.2023.12.017

Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study

Berit Skretting Solberg^*, Liv Grimstvedt Kvalvik, Johanne Telnes Instanes, Catharina A. Hartman, Kari Klungsøyr, Lin Li, Henrik Larsson, Per M Magnus, Pål Rasmus Njølstad, Stefan Johansson, Ole A. Andreassen, Nora Refsum Bakken, Mona Bekkhus, Chloe Austerberry, Dinka Smajlagic, Alexandra Havdahl, Elizabeth C. Corfield, Jan Haavik, Rolf Gjestad, Tetyana Zayats

^*Corresponding author for this work

Bristol Medical School (PHS)

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Abstract

Background: Epidemiological studies suggest that maternal diet quality during pregnancy may influence the risk of neurodevelopmental disorders in offspring. Here, we investigated associations between maternal intake of dietary fiber and attention-deficit/hyperactivity disorder (ADHD) symptoms in early childhood. Methods: We used longitudinal data of up to 21,852 mother-father-child trios (49.2% female offspring) from MoBa (the Norwegian Mother, Father, and Child Cohort Study). The relationships between maternal fiber intake during pregnancy and offspring ADHD symptoms at ages 3, 5, and 8 years were examined using 1) multivariate regression (overall levels of ADHD symptoms), 2) latent class analysis (subclasses of ADHD symptoms by sex at each age), and 3) latent growth curves (longitudinal change in offspring ADHD symptoms). Covariates were ADHD polygenic scores in child and parents, total energy intake and energy-adjusted sugar intake, parental ages at birth of the child, and sociodemographic factors. Results: Higher maternal prenatal fiber intake was associated with lower offspring ADHD symptom scores at all ages (B_age3 = −0.14 [95% CI, −0.18 to −0.10]; B_age5 = −0.14 [95% CI, −0.19 to −0.09]; B_age8 = −0.14 [95% CI, −0.20 to −0.09]). Of the derived low/middle/high subclasses of ADHD symptoms, fiber was associated with lower risk of belonging to the middle subclass for boys and girls and to the high subclass for girls only (middle: odds ratio_boys 0.91 [95% CI, 0.86 to 0.97]/odds ratio_girls 0.86 [95% CI, 0.81 to 0.91]; high: odds ratio_girls 0.82 [95% CI, 0.72 to 0.94]). Maternal fiber intake and rate of change in child ADHD symptoms across ages were not associated. Conclusions: Low prenatal maternal fiber intake may increase symptom levels of ADHD in offspring during childhood, independently of genetic predisposition to ADHD, unhealthy dietary exposures, and sociodemographic factors.

Original language	English
Pages (from-to)	839-848
Number of pages	10
Journal	Biological Psychiatry
Volume	95
Issue number	9
Early online date	22 Dec 2023
DOIs	https://doi.org/10.1016/j.biopsych.2023.12.017
Publication status	Published - 1 May 2024

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Publisher Copyright:
© 2023 Society of Biological Psychiatry

Keywords

ADHD
Genetics
MoBa
Pregnancy
Prenatal nutrition

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Solberg, B. S., Kvalvik, L. G., Instanes, J. T., Hartman, C. A., Klungsøyr, K., Li, L., Larsson, H., Magnus, P. M., Njølstad, P. R., Johansson, S., Andreassen, O. A., Bakken, N. R., Bekkhus, M., Austerberry, C., Smajlagic, D., Havdahl, A., Corfield, E. C., Haavik, J., Gjestad, R., & Zayats, T. (2024). Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study. Biological Psychiatry, 95(9), 839-848. https://doi.org/10.1016/j.biopsych.2023.12.017

@article{16cbfa6fd1f84f4281ce9d4a2f5acca2,

title = "Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study",

abstract = "Background: Epidemiological studies suggest that maternal diet quality during pregnancy may influence the risk of neurodevelopmental disorders in offspring. Here, we investigated associations between maternal intake of dietary fiber and attention-deficit/hyperactivity disorder (ADHD) symptoms in early childhood. Methods: We used longitudinal data of up to 21,852 mother-father-child trios (49.2\% female offspring) from MoBa (the Norwegian Mother, Father, and Child Cohort Study). The relationships between maternal fiber intake during pregnancy and offspring ADHD symptoms at ages 3, 5, and 8 years were examined using 1) multivariate regression (overall levels of ADHD symptoms), 2) latent class analysis (subclasses of ADHD symptoms by sex at each age), and 3) latent growth curves (longitudinal change in offspring ADHD symptoms). Covariates were ADHD polygenic scores in child and parents, total energy intake and energy-adjusted sugar intake, parental ages at birth of the child, and sociodemographic factors. Results: Higher maternal prenatal fiber intake was associated with lower offspring ADHD symptom scores at all ages (Bage3 = −0.14 [95\% CI, −0.18 to −0.10]; Bage5 = −0.14 [95\% CI, −0.19 to −0.09]; Bage8 = −0.14 [95\% CI, −0.20 to −0.09]). Of the derived low/middle/high subclasses of ADHD symptoms, fiber was associated with lower risk of belonging to the middle subclass for boys and girls and to the high subclass for girls only (middle: odds ratioboys 0.91 [95\% CI, 0.86 to 0.97]/odds ratiogirls 0.86 [95\% CI, 0.81 to 0.91]; high: odds ratiogirls 0.82 [95\% CI, 0.72 to 0.94]). Maternal fiber intake and rate of change in child ADHD symptoms across ages were not associated. Conclusions: Low prenatal maternal fiber intake may increase symptom levels of ADHD in offspring during childhood, independently of genetic predisposition to ADHD, unhealthy dietary exposures, and sociodemographic factors.",

keywords = "ADHD, Genetics, MoBa, Pregnancy, Prenatal nutrition",

author = "Solberg, \{Berit Skretting\} and Kvalvik, \{Liv Grimstvedt\} and Instanes, \{Johanne Telnes\} and Hartman, \{Catharina A.\} and Kari Klungs{\o}yr and Lin Li and Henrik Larsson and Magnus, \{Per M\} and Nj{\o}lstad, \{P{\aa}l Rasmus\} and Stefan Johansson and Andreassen, \{Ole A.\} and Bakken, \{Nora Refsum\} and Mona Bekkhus and Chloe Austerberry and Dinka Smajlagic and Alexandra Havdahl and Corfield, \{Elizabeth C.\} and Jan Haavik and Rolf Gjestad and Tetyana Zayats",

note = "Publisher Copyright: {\textcopyright} 2023 Society of Biological Psychiatry",

year = "2024",

month = may,

day = "1",

doi = "10.1016/j.biopsych.2023.12.017",

language = "English",

volume = "95",

pages = "839--848",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier Inc.",

number = "9",

}

Solberg, BS, Kvalvik, LG, Instanes, JT, Hartman, CA, Klungsøyr, K, Li, L, Larsson, H, Magnus, PM, Njølstad, PR, Johansson, S, Andreassen, OA, Bakken, NR, Bekkhus, M, Austerberry, C, Smajlagic, D, Havdahl, A, Corfield, EC, Haavik, J, Gjestad, R & Zayats, T 2024, 'Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study', Biological Psychiatry, vol. 95, no. 9, pp. 839-848. https://doi.org/10.1016/j.biopsych.2023.12.017

Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study. / Solberg, Berit Skretting; Kvalvik, Liv Grimstvedt; Instanes, Johanne Telnes et al.
In: Biological Psychiatry, Vol. 95, No. 9, 01.05.2024, p. 839-848.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood

T2 - The Norwegian Mother, Father, and Child Cohort Study

AU - Solberg, Berit Skretting

AU - Kvalvik, Liv Grimstvedt

AU - Instanes, Johanne Telnes

AU - Hartman, Catharina A.

AU - Klungsøyr, Kari

AU - Li, Lin

AU - Larsson, Henrik

AU - Magnus, Per M

AU - Njølstad, Pål Rasmus

AU - Johansson, Stefan

AU - Andreassen, Ole A.

AU - Bakken, Nora Refsum

AU - Bekkhus, Mona

AU - Austerberry, Chloe

AU - Smajlagic, Dinka

AU - Havdahl, Alexandra

AU - Corfield, Elizabeth C.

AU - Haavik, Jan

AU - Gjestad, Rolf

AU - Zayats, Tetyana

PY - 2024/5/1

Y1 - 2024/5/1

N2 - Background: Epidemiological studies suggest that maternal diet quality during pregnancy may influence the risk of neurodevelopmental disorders in offspring. Here, we investigated associations between maternal intake of dietary fiber and attention-deficit/hyperactivity disorder (ADHD) symptoms in early childhood. Methods: We used longitudinal data of up to 21,852 mother-father-child trios (49.2% female offspring) from MoBa (the Norwegian Mother, Father, and Child Cohort Study). The relationships between maternal fiber intake during pregnancy and offspring ADHD symptoms at ages 3, 5, and 8 years were examined using 1) multivariate regression (overall levels of ADHD symptoms), 2) latent class analysis (subclasses of ADHD symptoms by sex at each age), and 3) latent growth curves (longitudinal change in offspring ADHD symptoms). Covariates were ADHD polygenic scores in child and parents, total energy intake and energy-adjusted sugar intake, parental ages at birth of the child, and sociodemographic factors. Results: Higher maternal prenatal fiber intake was associated with lower offspring ADHD symptom scores at all ages (Bage3 = −0.14 [95% CI, −0.18 to −0.10]; Bage5 = −0.14 [95% CI, −0.19 to −0.09]; Bage8 = −0.14 [95% CI, −0.20 to −0.09]). Of the derived low/middle/high subclasses of ADHD symptoms, fiber was associated with lower risk of belonging to the middle subclass for boys and girls and to the high subclass for girls only (middle: odds ratioboys 0.91 [95% CI, 0.86 to 0.97]/odds ratiogirls 0.86 [95% CI, 0.81 to 0.91]; high: odds ratiogirls 0.82 [95% CI, 0.72 to 0.94]). Maternal fiber intake and rate of change in child ADHD symptoms across ages were not associated. Conclusions: Low prenatal maternal fiber intake may increase symptom levels of ADHD in offspring during childhood, independently of genetic predisposition to ADHD, unhealthy dietary exposures, and sociodemographic factors.

AB - Background: Epidemiological studies suggest that maternal diet quality during pregnancy may influence the risk of neurodevelopmental disorders in offspring. Here, we investigated associations between maternal intake of dietary fiber and attention-deficit/hyperactivity disorder (ADHD) symptoms in early childhood. Methods: We used longitudinal data of up to 21,852 mother-father-child trios (49.2% female offspring) from MoBa (the Norwegian Mother, Father, and Child Cohort Study). The relationships between maternal fiber intake during pregnancy and offspring ADHD symptoms at ages 3, 5, and 8 years were examined using 1) multivariate regression (overall levels of ADHD symptoms), 2) latent class analysis (subclasses of ADHD symptoms by sex at each age), and 3) latent growth curves (longitudinal change in offspring ADHD symptoms). Covariates were ADHD polygenic scores in child and parents, total energy intake and energy-adjusted sugar intake, parental ages at birth of the child, and sociodemographic factors. Results: Higher maternal prenatal fiber intake was associated with lower offspring ADHD symptom scores at all ages (Bage3 = −0.14 [95% CI, −0.18 to −0.10]; Bage5 = −0.14 [95% CI, −0.19 to −0.09]; Bage8 = −0.14 [95% CI, −0.20 to −0.09]). Of the derived low/middle/high subclasses of ADHD symptoms, fiber was associated with lower risk of belonging to the middle subclass for boys and girls and to the high subclass for girls only (middle: odds ratioboys 0.91 [95% CI, 0.86 to 0.97]/odds ratiogirls 0.86 [95% CI, 0.81 to 0.91]; high: odds ratiogirls 0.82 [95% CI, 0.72 to 0.94]). Maternal fiber intake and rate of change in child ADHD symptoms across ages were not associated. Conclusions: Low prenatal maternal fiber intake may increase symptom levels of ADHD in offspring during childhood, independently of genetic predisposition to ADHD, unhealthy dietary exposures, and sociodemographic factors.

KW - ADHD

KW - Genetics

KW - MoBa

KW - Pregnancy

KW - Prenatal nutrition

U2 - 10.1016/j.biopsych.2023.12.017

DO - 10.1016/j.biopsych.2023.12.017

M3 - Article (Academic Journal)

C2 - 38142720

AN - SCOPUS:85185598657

SN - 0006-3223

VL - 95

SP - 839

EP - 848

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 9

ER -

Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study

Abstract

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