Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City

J Richard Pilsner, Howard Hu, Robert O Wright, Katarzyna Kordas, Adrienne S Ettinger, Brisa N Sánchez, David Cantonwine, Alicia L Lazarus, Alejandra Cantoral, Lourdes Schnaas, Martha Maria Téllez-Rojo, Mauricio Hernández-Avila

Research output: Contribution to journalArticle (Academic Journal)peer-review

23 Citations (Scopus)

Abstract

Maternal folate nutritional status and prenatal lead exposure can influence fetal development and subsequent health. The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 common polymorphisms, C677T and A1298C, reduce enzymatic activity; C677T is present at high penetrance in Mexican populations.
Original languageEnglish
Pages (from-to)226-34
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume92
Issue number1
DOIs
Publication statusPublished - Jul 2010

Keywords

  • Adolescent
  • Adult
  • Bone and Bones
  • Child, Preschool
  • Cognition Disorders
  • Developmental Disabilities
  • Dietary Supplements
  • Energy Intake
  • Female
  • Genetic Linkage
  • Genotype
  • Haplotypes
  • Humans
  • Lead
  • Lead Poisoning
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Mexico
  • Mothers
  • Parity
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Postpartum Period
  • Pregnancy
  • Regression Analysis

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