Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City

J Richard Pilsner; Howard Hu; Robert O Wright; Katarzyna Kordas; Adrienne S Ettinger; Brisa N Sánchez; David Cantonwine; Alicia L Lazarus; Alejandra Cantoral; Lourdes Schnaas; Martha Maria Téllez-Rojo; Mauricio Hernández-Avila

doi:10.3945/ajcn.2009.28839

Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City

J Richard Pilsner
, Howard Hu
, Robert O Wright
, Katarzyna Kordas
, Adrienne S Ettinger
, Brisa N Sánchez
, David Cantonwine
, Alicia L Lazarus
, Alejandra Cantoral
, Lourdes Schnaas
, Martha Maria Téllez-Rojo
, Mauricio Hernández-Avila

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

36 Citations (Scopus)

Abstract

Maternal folate nutritional status and prenatal lead exposure can influence fetal development and subsequent health. The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 common polymorphisms, C677T and A1298C, reduce enzymatic activity; C677T is present at high penetrance in Mexican populations.

Original language	English
Pages (from-to)	226-34
Number of pages	9
Journal	American Journal of Clinical Nutrition
Volume	92
Issue number	1
DOIs	https://doi.org/10.3945/ajcn.2009.28839
Publication status	Published - Jul 2010

Keywords

Adolescent
Adult
Bone and Bones
Child, Preschool
Cognition Disorders
Developmental Disabilities
Dietary Supplements
Energy Intake
Female
Genetic Linkage
Genotype
Haplotypes
Humans
Lead
Lead Poisoning
Methylenetetrahydrofolate Reductase (NADPH2)
Mexico
Mothers
Parity
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Postpartum Period
Pregnancy
Regression Analysis

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Pilsner, J. R., Hu, H., Wright, R. O., Kordas, K., Ettinger, A. S., Sánchez, B. N., Cantonwine, D., Lazarus, A. L., Cantoral, A., Schnaas, L., Téllez-Rojo, M. M., & Hernández-Avila, M. (2010). Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City. American Journal of Clinical Nutrition, 92(1), 226-34. https://doi.org/10.3945/ajcn.2009.28839

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title = "Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City",

abstract = "Maternal folate nutritional status and prenatal lead exposure can influence fetal development and subsequent health. The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 common polymorphisms, C677T and A1298C, reduce enzymatic activity; C677T is present at high penetrance in Mexican populations.",

keywords = "Adolescent, Adult, Bone and Bones, Child, Preschool, Cognition Disorders, Developmental Disabilities, Dietary Supplements, Energy Intake, Female, Genetic Linkage, Genotype, Haplotypes, Humans, Lead, Lead Poisoning, Methylenetetrahydrofolate Reductase (NADPH2), Mexico, Mothers, Parity, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Postpartum Period, Pregnancy, Regression Analysis",

author = "Pilsner, \{J Richard\} and Howard Hu and Wright, \{Robert O\} and Katarzyna Kordas and Ettinger, \{Adrienne S\} and S{\'a}nchez, \{Brisa N\} and David Cantonwine and Lazarus, \{Alicia L\} and Alejandra Cantoral and Lourdes Schnaas and T{\'e}llez-Rojo, \{Martha Maria\} and Mauricio Hern{\'a}ndez-Avila",

year = "2010",

month = jul,

doi = "10.3945/ajcn.2009.28839",

language = "English",

volume = "92",

pages = "226--34",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

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Pilsner, JR, Hu, H, Wright, RO, Kordas, K, Ettinger, AS, Sánchez, BN, Cantonwine, D, Lazarus, AL, Cantoral, A, Schnaas, L, Téllez-Rojo, MM & Hernández-Avila, M 2010, 'Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City', American Journal of Clinical Nutrition, vol. 92, no. 1, pp. 226-34. https://doi.org/10.3945/ajcn.2009.28839

TY - JOUR

T1 - Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City

AU - Pilsner, J Richard

AU - Hu, Howard

AU - Wright, Robert O

AU - Kordas, Katarzyna

AU - Ettinger, Adrienne S

AU - Sánchez, Brisa N

AU - Cantonwine, David

AU - Lazarus, Alicia L

AU - Cantoral, Alejandra

AU - Schnaas, Lourdes

AU - Téllez-Rojo, Martha Maria

AU - Hernández-Avila, Mauricio

PY - 2010/7

Y1 - 2010/7

N2 - Maternal folate nutritional status and prenatal lead exposure can influence fetal development and subsequent health. The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 common polymorphisms, C677T and A1298C, reduce enzymatic activity; C677T is present at high penetrance in Mexican populations.

AB - Maternal folate nutritional status and prenatal lead exposure can influence fetal development and subsequent health. The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 common polymorphisms, C677T and A1298C, reduce enzymatic activity; C677T is present at high penetrance in Mexican populations.

KW - Adolescent

KW - Adult

KW - Bone and Bones

KW - Child, Preschool

KW - Cognition Disorders

KW - Developmental Disabilities

KW - Dietary Supplements

KW - Energy Intake

KW - Female

KW - Genetic Linkage

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Lead

KW - Lead Poisoning

KW - Methylenetetrahydrofolate Reductase (NADPH2)

KW - Mexico

KW - Mothers

KW - Parity

KW - Polymorphism, Genetic

KW - Polymorphism, Single Nucleotide

KW - Postpartum Period

KW - Pregnancy

KW - Regression Analysis

U2 - 10.3945/ajcn.2009.28839

DO - 10.3945/ajcn.2009.28839

M3 - Article (Academic Journal)

C2 - 20504979

SN - 0002-9165

VL - 92

SP - 226

EP - 234

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 1

ER -

Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City

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