Maternal Prenatal Mood, Pregnancy-Specific Worries, and Early Child Psychopathology: Findings From the DREAM BIG Consortium

Eszter Szekely; Hannah Sallis; Rebecca M Pearson; Jonathan Evans; Ashley Wazana; et al.

doi:10.1016/j.jaac.2020.02.017

Maternal Prenatal Mood, Pregnancy-Specific Worries, and Early Child Psychopathology: Findings From the DREAM BIG Consortium

Eszter Szekely, Hannah Sallis, Rebecca M Pearson, Jonathan Evans, Ashley Wazana, et al.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Objective: Few studies have attempted to identify how distinct dimensions of maternal prenatal affective symptoms relate to offspring psychopathology. We defined latent dimensions of women's prenatal affective symptoms and pregnancy-specific worries to examined their association with early offspring psychopathology in three prenatal cohorts.

Method: Data were used from three cohorts of the DREAM-BIG consortium: Avon Longitudinal Study of Parents and Children (ALSPAC [N=12,515]), Generation R (N=6,803), and the Canadian prenatal cohort Maternal Adversity, Vulnerability, and Neurodevelopment (MAVAN [N=578]). Maternal prenatal affective symptoms and pregnancy-specific worries were assessed using different measures in each cohort. Through confirmatory factor analyses we determined whether comparable latent dimensions of prenatal maternal affective symptoms exist across the cohorts. We used structural equation models to examine cohort-specific associations between these dimensions and offspring psychopathology at 4-8 years of age (general psychopathology, specific internalizing and externalizing previously derived using confirmatory factor analyses). Cohort-based estimates were meta-analyzed using inverse variance-weighing.

Results: Four prenatal maternal factors were similar in all cohorts: a general affective symptoms factor and three specific factors-an anxiety/depression factor; a somatic factor; and a pregnancy-specific worries factor. In meta-analyses, both the general affective symptoms factor and pregnancy-specific worries factor were independently associated with offspring general psychopathology. The general affective symptoms factor was further associated with offspring specific internalizing problems. There were no associations with specific externalizing problems.

Conclusion: These replicated findings of independent and adverse effects for prenatal general affective symptoms and pregnancy-specific worries on child mental health support the need for specific interventions in pregnancy.

Keywords: child externalizing; child internalizing; p factor; pregnancy anxiety; prenatal depression.

Original language	English
Pages (from-to)	186-197
Number of pages	12
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	60
Issue number	1
Early online date	8 Apr 2020
DOIs	https://doi.org/10.1016/j.jaac.2020.02.017
Publication status	Published - 1 Jan 2021

Bibliographical note

Funding Information:
A. Neumann and H. Tiemeier are supported by a grant of the Dutch Ministry of Education, Culture, and Science and the Netherlands Organization for Scientific Research (NOW; grant no. 024.001.003, Consortium on Individual Development). The work of H. Tiemeier is supported by NWO-VICI grant (NWO-ZonMW: 016.VICI.170.200). R.D. Levitan has acknowledged support from the Cameron Parker Holcombe Wilson Chair in Depression Studies, University of Toronto and the Centre for Addiction and Mental Health (CAMH).

Funding Information:
This research was made possible by the Canadian Institutes of Health Research (CIHR; grants 359912, 365309, and 231614), the Fonds de la recherche en santé du Québec (FRSQ; grant 22418), and the March of Dimes Foundation (grant 12-FY12-198). The UK Medical Research Council (grant reference74882), the Wellcome Trust (grant reference 076467), and the University of Bristol provide core support for the Avon Longitudinal Study of Parents and Children (ALSPAC).

Funding Information:
This research was made possible by the Canadian Institutes of Health Research (CIHR; grants 359912, 365309, and 231614), the Fonds de la recherche en sant? du Qu?bec (FRSQ; grant 22418), and the March of Dimes Foundation (grant 12-FY12-198). The UK Medical Research Council (grant reference74882), the Wellcome Trust (grant reference 076467), and the University of Bristol provide core support for the Avon Longitudinal Study of Parents and Children (ALSPAC). The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the Erasmus University Rotterdam, Faculty of Social Sciences, the Municipal Health Service Rotterdam area, and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. The Generation R Study is made possible by financial support from Erasmus Medical Center, Rotterdam, and the Netherlands Organization for Health Research and Development (ZonMw). A. Neumann and H. Tiemeier are supported by a grant of the Dutch Ministry of Education, Culture, and Science and the Netherlands Organization for Scientific Research (NOW; grant no. 024.001.003, Consortium on Individual Development). The work of H. Tiemeier is supported by NWO-VICI grant (NWO-ZonMW: 016.VICI.170.200). R.D. Levitan has acknowledged support from the Cameron Parker Holcombe Wilson Chair in Depression Studies, University of Toronto and the Centre for Addiction and Mental Health (CAMH). Funding acquisition: Szekely, Verhulst, Meaney, Levitan, Kennedy, Lydon, Steiner, Greenwood, Tiemeier, Evans, Wazana Disclosure: Dr. Verhulst is a contributing author of the Achenbach System of Empirically Based Assessment (ASEBA), from which he has received remuneration. Drs. Szekely, Neumann, Sallis, Meaney, Pearson, Levitan, Kennedy, Lydon, Steiner, Greenwood, Tiemeier, Evans, and Wazana and Ms. Jolicoeur-Martineau have reported no biomedical financial interests or potential conflicts of interest.

Funding Information:
The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the Erasmus University Rotterdam, Faculty of Social Sciences, the Municipal Health Service Rotterdam area, and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. The Generation R Study is made possible by financial support from Erasmus Medical Center, Rotterdam, and the Netherlands Organization for Health Research and Development (ZonMw).

Publisher Copyright:
© 2020 The Authors

Keywords

prenatal depression
pregnancy anxiety
child internalizing
child externalizing
p factor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Dr Jonathan Evans
- J.Evansbristol.acuk
- Bristol Medical School (PHS) - Consultant Senior Lecturer
Person: Academic

Cite this

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title = "Maternal Prenatal Mood, Pregnancy-Specific Worries, and Early Child Psychopathology: Findings From the DREAM BIG Consortium",

abstract = "Objective: Few studies have attempted to identify how distinct dimensions of maternal prenatal affective symptoms relate to offspring psychopathology. We defined latent dimensions of women's prenatal affective symptoms and pregnancy-specific worries to examined their association with early offspring psychopathology in three prenatal cohorts.Method: Data were used from three cohorts of the DREAM-BIG consortium: Avon Longitudinal Study of Parents and Children (ALSPAC [N=12,515]), Generation R (N=6,803), and the Canadian prenatal cohort Maternal Adversity, Vulnerability, and Neurodevelopment (MAVAN [N=578]). Maternal prenatal affective symptoms and pregnancy-specific worries were assessed using different measures in each cohort. Through confirmatory factor analyses we determined whether comparable latent dimensions of prenatal maternal affective symptoms exist across the cohorts. We used structural equation models to examine cohort-specific associations between these dimensions and offspring psychopathology at 4-8 years of age (general psychopathology, specific internalizing and externalizing previously derived using confirmatory factor analyses). Cohort-based estimates were meta-analyzed using inverse variance-weighing.Results: Four prenatal maternal factors were similar in all cohorts: a general affective symptoms factor and three specific factors-an anxiety/depression factor; a somatic factor; and a pregnancy-specific worries factor. In meta-analyses, both the general affective symptoms factor and pregnancy-specific worries factor were independently associated with offspring general psychopathology. The general affective symptoms factor was further associated with offspring specific internalizing problems. There were no associations with specific externalizing problems.Conclusion: These replicated findings of independent and adverse effects for prenatal general affective symptoms and pregnancy-specific worries on child mental health support the need for specific interventions in pregnancy.Keywords: child externalizing; child internalizing; p factor; pregnancy anxiety; prenatal depression.",

keywords = "prenatal depression, pregnancy anxiety, child internalizing, child externalizing, p factor",

author = "Eszter Szekely and Hannah Sallis and Pearson, {Rebecca M} and Jonathan Evans and Ashley Wazana and et al.",

note = "Funding Information: A. Neumann and H. Tiemeier are supported by a grant of the Dutch Ministry of Education, Culture, and Science and the Netherlands Organization for Scientific Research (NOW; grant no. 024.001.003, Consortium on Individual Development). The work of H. Tiemeier is supported by NWO-VICI grant (NWO-ZonMW: 016.VICI.170.200). R.D. Levitan has acknowledged support from the Cameron Parker Holcombe Wilson Chair in Depression Studies, University of Toronto and the Centre for Addiction and Mental Health (CAMH). Funding Information: This research was made possible by the Canadian Institutes of Health Research (CIHR; grants 359912, 365309, and 231614), the Fonds de la recherche en sant{\'e} du Qu{\'e}bec (FRSQ; grant 22418), and the March of Dimes Foundation (grant 12-FY12-198). The UK Medical Research Council (grant reference74882), the Wellcome Trust (grant reference 076467), and the University of Bristol provide core support for the Avon Longitudinal Study of Parents and Children (ALSPAC). Funding Information: This research was made possible by the Canadian Institutes of Health Research (CIHR; grants 359912, 365309, and 231614), the Fonds de la recherche en sant? du Qu?bec (FRSQ; grant 22418), and the March of Dimes Foundation (grant 12-FY12-198). The UK Medical Research Council (grant reference74882), the Wellcome Trust (grant reference 076467), and the University of Bristol provide core support for the Avon Longitudinal Study of Parents and Children (ALSPAC). The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the Erasmus University Rotterdam, Faculty of Social Sciences, the Municipal Health Service Rotterdam area, and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. The Generation R Study is made possible by financial support from Erasmus Medical Center, Rotterdam, and the Netherlands Organization for Health Research and Development (ZonMw). A. Neumann and H. Tiemeier are supported by a grant of the Dutch Ministry of Education, Culture, and Science and the Netherlands Organization for Scientific Research (NOW; grant no. 024.001.003, Consortium on Individual Development). The work of H. Tiemeier is supported by NWO-VICI grant (NWO-ZonMW: 016.VICI.170.200). R.D. Levitan has acknowledged support from the Cameron Parker Holcombe Wilson Chair in Depression Studies, University of Toronto and the Centre for Addiction and Mental Health (CAMH). Funding acquisition: Szekely, Verhulst, Meaney, Levitan, Kennedy, Lydon, Steiner, Greenwood, Tiemeier, Evans, Wazana Disclosure: Dr. Verhulst is a contributing author of the Achenbach System of Empirically Based Assessment (ASEBA), from which he has received remuneration. Drs. Szekely, Neumann, Sallis, Meaney, Pearson, Levitan, Kennedy, Lydon, Steiner, Greenwood, Tiemeier, Evans, and Wazana and Ms. Jolicoeur-Martineau have reported no biomedical financial interests or potential conflicts of interest. Funding Information: The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the Erasmus University Rotterdam, Faculty of Social Sciences, the Municipal Health Service Rotterdam area, and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. The Generation R Study is made possible by financial support from Erasmus Medical Center, Rotterdam, and the Netherlands Organization for Health Research and Development (ZonMw). Publisher Copyright: {\textcopyright} 2020 The Authors",

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language = "English",

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Maternal Prenatal Mood, Pregnancy-Specific Worries, and Early Child Psychopathology: Findings From the DREAM BIG Consortium. / Szekely, Eszter; Sallis, Hannah ; Pearson, Rebecca M et al.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 60, No. 1, 01.01.2021, p. 186-197.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Maternal Prenatal Mood, Pregnancy-Specific Worries, and Early Child Psychopathology

T2 - Findings From the DREAM BIG Consortium

AU - Szekely, Eszter

AU - Sallis, Hannah

AU - Pearson, Rebecca M

AU - Evans, Jonathan

AU - Wazana, Ashley

AU - al., et

N1 - Funding Information: A. Neumann and H. Tiemeier are supported by a grant of the Dutch Ministry of Education, Culture, and Science and the Netherlands Organization for Scientific Research (NOW; grant no. 024.001.003, Consortium on Individual Development). The work of H. Tiemeier is supported by NWO-VICI grant (NWO-ZonMW: 016.VICI.170.200). R.D. Levitan has acknowledged support from the Cameron Parker Holcombe Wilson Chair in Depression Studies, University of Toronto and the Centre for Addiction and Mental Health (CAMH). Funding Information: This research was made possible by the Canadian Institutes of Health Research (CIHR; grants 359912, 365309, and 231614), the Fonds de la recherche en santé du Québec (FRSQ; grant 22418), and the March of Dimes Foundation (grant 12-FY12-198). The UK Medical Research Council (grant reference74882), the Wellcome Trust (grant reference 076467), and the University of Bristol provide core support for the Avon Longitudinal Study of Parents and Children (ALSPAC). Funding Information: This research was made possible by the Canadian Institutes of Health Research (CIHR; grants 359912, 365309, and 231614), the Fonds de la recherche en sant? du Qu?bec (FRSQ; grant 22418), and the March of Dimes Foundation (grant 12-FY12-198). The UK Medical Research Council (grant reference74882), the Wellcome Trust (grant reference 076467), and the University of Bristol provide core support for the Avon Longitudinal Study of Parents and Children (ALSPAC). The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the Erasmus University Rotterdam, Faculty of Social Sciences, the Municipal Health Service Rotterdam area, and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. The Generation R Study is made possible by financial support from Erasmus Medical Center, Rotterdam, and the Netherlands Organization for Health Research and Development (ZonMw). A. Neumann and H. Tiemeier are supported by a grant of the Dutch Ministry of Education, Culture, and Science and the Netherlands Organization for Scientific Research (NOW; grant no. 024.001.003, Consortium on Individual Development). The work of H. Tiemeier is supported by NWO-VICI grant (NWO-ZonMW: 016.VICI.170.200). R.D. Levitan has acknowledged support from the Cameron Parker Holcombe Wilson Chair in Depression Studies, University of Toronto and the Centre for Addiction and Mental Health (CAMH). Funding acquisition: Szekely, Verhulst, Meaney, Levitan, Kennedy, Lydon, Steiner, Greenwood, Tiemeier, Evans, Wazana Disclosure: Dr. Verhulst is a contributing author of the Achenbach System of Empirically Based Assessment (ASEBA), from which he has received remuneration. Drs. Szekely, Neumann, Sallis, Meaney, Pearson, Levitan, Kennedy, Lydon, Steiner, Greenwood, Tiemeier, Evans, and Wazana and Ms. Jolicoeur-Martineau have reported no biomedical financial interests or potential conflicts of interest. Funding Information: The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the Erasmus University Rotterdam, Faculty of Social Sciences, the Municipal Health Service Rotterdam area, and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. The Generation R Study is made possible by financial support from Erasmus Medical Center, Rotterdam, and the Netherlands Organization for Health Research and Development (ZonMw). Publisher Copyright: © 2020 The Authors

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Objective: Few studies have attempted to identify how distinct dimensions of maternal prenatal affective symptoms relate to offspring psychopathology. We defined latent dimensions of women's prenatal affective symptoms and pregnancy-specific worries to examined their association with early offspring psychopathology in three prenatal cohorts.Method: Data were used from three cohorts of the DREAM-BIG consortium: Avon Longitudinal Study of Parents and Children (ALSPAC [N=12,515]), Generation R (N=6,803), and the Canadian prenatal cohort Maternal Adversity, Vulnerability, and Neurodevelopment (MAVAN [N=578]). Maternal prenatal affective symptoms and pregnancy-specific worries were assessed using different measures in each cohort. Through confirmatory factor analyses we determined whether comparable latent dimensions of prenatal maternal affective symptoms exist across the cohorts. We used structural equation models to examine cohort-specific associations between these dimensions and offspring psychopathology at 4-8 years of age (general psychopathology, specific internalizing and externalizing previously derived using confirmatory factor analyses). Cohort-based estimates were meta-analyzed using inverse variance-weighing.Results: Four prenatal maternal factors were similar in all cohorts: a general affective symptoms factor and three specific factors-an anxiety/depression factor; a somatic factor; and a pregnancy-specific worries factor. In meta-analyses, both the general affective symptoms factor and pregnancy-specific worries factor were independently associated with offspring general psychopathology. The general affective symptoms factor was further associated with offspring specific internalizing problems. There were no associations with specific externalizing problems.Conclusion: These replicated findings of independent and adverse effects for prenatal general affective symptoms and pregnancy-specific worries on child mental health support the need for specific interventions in pregnancy.Keywords: child externalizing; child internalizing; p factor; pregnancy anxiety; prenatal depression.

AB - Objective: Few studies have attempted to identify how distinct dimensions of maternal prenatal affective symptoms relate to offspring psychopathology. We defined latent dimensions of women's prenatal affective symptoms and pregnancy-specific worries to examined their association with early offspring psychopathology in three prenatal cohorts.Method: Data were used from three cohorts of the DREAM-BIG consortium: Avon Longitudinal Study of Parents and Children (ALSPAC [N=12,515]), Generation R (N=6,803), and the Canadian prenatal cohort Maternal Adversity, Vulnerability, and Neurodevelopment (MAVAN [N=578]). Maternal prenatal affective symptoms and pregnancy-specific worries were assessed using different measures in each cohort. Through confirmatory factor analyses we determined whether comparable latent dimensions of prenatal maternal affective symptoms exist across the cohorts. We used structural equation models to examine cohort-specific associations between these dimensions and offspring psychopathology at 4-8 years of age (general psychopathology, specific internalizing and externalizing previously derived using confirmatory factor analyses). Cohort-based estimates were meta-analyzed using inverse variance-weighing.Results: Four prenatal maternal factors were similar in all cohorts: a general affective symptoms factor and three specific factors-an anxiety/depression factor; a somatic factor; and a pregnancy-specific worries factor. In meta-analyses, both the general affective symptoms factor and pregnancy-specific worries factor were independently associated with offspring general psychopathology. The general affective symptoms factor was further associated with offspring specific internalizing problems. There were no associations with specific externalizing problems.Conclusion: These replicated findings of independent and adverse effects for prenatal general affective symptoms and pregnancy-specific worries on child mental health support the need for specific interventions in pregnancy.Keywords: child externalizing; child internalizing; p factor; pregnancy anxiety; prenatal depression.

KW - prenatal depression

KW - pregnancy anxiety

KW - child internalizing

KW - child externalizing

KW - p factor

U2 - 10.1016/j.jaac.2020.02.017

DO - 10.1016/j.jaac.2020.02.017

M3 - Article (Academic Journal)

C2 - 32278003

SN - 0890-8567

VL - 60

SP - 186

EP - 197

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

IS - 1

ER -

Maternal Prenatal Mood, Pregnancy-Specific Worries, and Early Child Psychopathology: Findings From the DREAM BIG Consortium

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