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Maternal serum concentrations of perfluoroalkyl substances during pregnancy and gestational weight gain: The Avon Longitudinal Study of Parents and Children

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalReproductive Toxicology
Early online date12 Aug 2019
DateSubmitted - 30 Jul 2019
DateAccepted/In press - 2 Aug 2019
DateE-pub ahead of print - 12 Aug 2019
DatePublished (current) - 1 Dec 2019


Perfluoroalkyl substances (PFAS) are chemicals used in the manufacture of consumer products. PFAS may act as endocrine disruptors, influencing metabolic pathways and weight[HYPHEN]related outcomes. Previous studies observed an association between perfluorooctane sulfonic acid (PFOS) and higher gestational weight gain among under[HYPHEN]/normal weight mothers. We analyzed associations of maternal serum pregnancy concentrations of PFAS with gestational weight gain (GWG) using data from 905 women in a subsample of the Avon Longitudinal Study of Parents and Children. Women were routinely weighed in antenatal check[HYPHEN]ups; absolute GWG was determined by subtracting the first weight measurement from the last. Linear regression was used to explore associations of maternal PFAS concentrations with absolute GWG, stratified by prepregnancy body mass index. Associations of maternal PFOS, perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) concentrations with absolute GWG were null; 10% higher PFOS was associated with GWG of [HYPHEN]0.03 kg (95% CI: [HYPHEN]0.11, 0.06) among under[HYPHEN]/normal weight mothers. Ten percent higher perfluorononanoic acid (PFNA) was associated with a higher GWG of 0.09 kg (95% CI: 0.02, 0.16) among under[HYPHEN]/normal weight mothers. Overall, findings suggest no association between maternal PFOA, PFOS, and PFHxS concentrations and GWG, and a weak positive association between maternal PFNA and GWG.

    Research areas

  • ALSPAC, Endocrine disruptors, Gestational weight gain, Perfluoroalkyl substances, Perfluorohexane sulfonic acid (PFHxS), Perfluorononanoic acid (PFNA), Perfluorooctane sulfonic acid (PFOS), Perfluorooctanoic acid (PFOA)



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    Embargo ends: 12/08/20

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    Licence: CC BY-NC-ND


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