Maternal serum transformed alpha-fetoprotein levels in women with intrauterine growth retardation

Jose L. Bartha*, Sebastian Illanes, Fernando Gonzalez-Bugatto, Sherif A. Abdel-Fattah, Gerald J. Mizejewski, Peter W. Soothill

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)

Abstract

Objective: To evaluate maternal serum transformed alpha-fetoprotein (t-AFP) levels in women with intrauterine growth retardation (IUGR). Methods: 60 pregnant women in two groups were studied: 30 with IUGR and 30 healthy pregnant women as a control group. t-AFP concentrations were determined by ELISA assay. Results: Maternal serum t-AFP levels were higher in women with IUGR than in the control group: 15.39 (10.81-24.01) ng/ml vs. 8.66 (6.22-13.45) ng/ml (p= 0.003). t-AFP levels were even higher in those with fetal hemodynamic redistribution 21.08 (16.02-40.85) ng/ml than in those without 12.15 (10.48-17.45) ng/ml (p = 0.03). Conclusions: Maternal serum t-AFP is increased in women with IUGR and this elevation is marked in those with fetal hemodynamic redistribution. Copyright (c) 2007 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)294-298
Number of pages5
JournalFetal Diagnosis and Therapy
Volume22
Issue number4
DOIs
Publication statusPublished - 2007

Keywords

  • alpha-fetoprotein
  • growth retardation
  • pregnancy complications
  • LOW-BIRTH-WEIGHT
  • RESTRICTED FETUS
  • PEPTIDES
  • DELIVERY
  • TERM
  • GESTATION
  • PREGNANCY

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