Maternal smoking during pregnancy and offspring smoking initiation: Assessing the role of intrauterine exposure

Amy E. Taylor; Laura D. Howe; Jon E. Heron; Jennifer J. Ware; Matthew Hickman; Marcus R. Munafo

doi:10.1111/add.12514

Maternal smoking during pregnancy and offspring smoking initiation: Assessing the role of intrauterine exposure

Amy E. Taylor^*, Laura D. Howe, Jon E. Heron, Jennifer J. Ware, Matthew Hickman, Marcus R. Munafo

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

43 Citations (Scopus)

Abstract

AimsTo assess whether associations between maternal smoking during pregnancy and offspring smoking initiation are due to intrauterine mechanisms.

DesignComparison of associations of maternal and partner smoking behaviour during pregnancy with offspring smoking initiation using partner smoking as a negative control (n=6484) and a Mendelian randomization analysis (n=1020), using a genetic variant in the mothers as a proxy for smoking cessation during pregnancy.

SettingA longitudinal birth cohort in South West England.

ParticipantsParticipants of the Avon Longitudinal Study of Parents and Children (ALSPAC).

MeasurementsSmoking status during pregnancy was self-reported by mother and partner in questionnaires administered at pregnancy. Latent classes of offspring smoking initiation (non-smokers, experimenters, late-onset regular smokers and early-onset regular smokers) were previously developed from questionnaires administered at 14-16 years. A genetic variant, rs1051730, was genotyped in the mothers.

FindingsBoth mother and partner smoking were similarly positively associated with offspring smoking initiation classes, even after adjustment for confounders. Odds ratios (OR) [95% confidence interval (CI)] for class membership compared with non-smokers were: experimenters: mother OR=1.33 (95% CI=1.06, 1.67), partner OR=1.28 (95% CI=1.06, 1.55), late-onset regular smokers: mother OR=1.80 (95% CI=1.43, 2.26), partner OR=1.86 (95% CI=1.52, 2.28) and early-onset regular smokers: mother OR=2.89 (95% CI=2.12, 3.94), partner OR=2.50 (95% CI=1.85, 3.37). There was no clear evidence for a dose-response effect of either mother or partner smoking heaviness on class membership. Maternal rs1051730 genotype was not clearly associated with offspring smoking initiation class in pre-pregnancy smokers (P=0.35).

ConclusionThe association between smoking during pregnancy and offspring smoking initiation does not appear to operate through intrauterine mechanisms.

Original language	English
Pages (from-to)	1013-1021
Number of pages	9
Journal	Addiction
Volume	109
Issue number	6
DOIs	https://doi.org/10.1111/add.12514
Publication status	Published - Jun 2014

Bibliographical note

Research Groups and Themes

Brain and Behaviour
Tobacco and Alcohol

Keywords

ALSPAC
intrauterine
maternal smoking
Mendelian randomization
negative control
offspring smoking
pregnancy
tobacco
PRENATAL NICOTINE EXPOSURE
SELF-REPORTED SMOKING
ADOLESCENT SMOKING
TOBACCO EXPOSURE
SUBSTANCE USE
GENE-CLUSTER
BEHAVIOR
MOTHERS
RISK
METAANALYSIS

Access to Document

10.1111/add.12514

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Persistent link

MRC UoB UNITE Unit - programme 3
Timpson, N. J. (Principal Investigator) & Timpson, N. J. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
MRC UoB UNITE Unit - Programme 6
Munafo, M. R. (Principal Investigator) & Munafo, M. R. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
Using Mendelian Randomisation to Establish the Causal Role of Cigarette Smoking in Anxiety and Depression
Munafo, M. R. (Principal Investigator)
1/11/12 → 1/11/13
Project: Research

Cite this

@article{79bfbcf080af48438f83a54d83266d3b,

title = "Maternal smoking during pregnancy and offspring smoking initiation: Assessing the role of intrauterine exposure",

abstract = "AimsTo assess whether associations between maternal smoking during pregnancy and offspring smoking initiation are due to intrauterine mechanisms.DesignComparison of associations of maternal and partner smoking behaviour during pregnancy with offspring smoking initiation using partner smoking as a negative control (n=6484) and a Mendelian randomization analysis (n=1020), using a genetic variant in the mothers as a proxy for smoking cessation during pregnancy.SettingA longitudinal birth cohort in South West England.ParticipantsParticipants of the Avon Longitudinal Study of Parents and Children (ALSPAC).MeasurementsSmoking status during pregnancy was self-reported by mother and partner in questionnaires administered at pregnancy. Latent classes of offspring smoking initiation (non-smokers, experimenters, late-onset regular smokers and early-onset regular smokers) were previously developed from questionnaires administered at 14-16 years. A genetic variant, rs1051730, was genotyped in the mothers.FindingsBoth mother and partner smoking were similarly positively associated with offspring smoking initiation classes, even after adjustment for confounders. Odds ratios (OR) [95% confidence interval (CI)] for class membership compared with non-smokers were: experimenters: mother OR=1.33 (95% CI=1.06, 1.67), partner OR=1.28 (95% CI=1.06, 1.55), late-onset regular smokers: mother OR=1.80 (95% CI=1.43, 2.26), partner OR=1.86 (95% CI=1.52, 2.28) and early-onset regular smokers: mother OR=2.89 (95% CI=2.12, 3.94), partner OR=2.50 (95% CI=1.85, 3.37). There was no clear evidence for a dose-response effect of either mother or partner smoking heaviness on class membership. Maternal rs1051730 genotype was not clearly associated with offspring smoking initiation class in pre-pregnancy smokers (P=0.35).ConclusionThe association between smoking during pregnancy and offspring smoking initiation does not appear to operate through intrauterine mechanisms.",

keywords = "ALSPAC, intrauterine, maternal smoking, Mendelian randomization, negative control, offspring smoking, pregnancy, tobacco, PRENATAL NICOTINE EXPOSURE, SELF-REPORTED SMOKING, ADOLESCENT SMOKING, TOBACCO EXPOSURE, SUBSTANCE USE, GENE-CLUSTER, BEHAVIOR, MOTHERS, RISK, METAANALYSIS",

author = "Taylor, {Amy E.} and Howe, {Laura D.} and Heron, {Jon E.} and Ware, {Jennifer J.} and Matthew Hickman and Munafo, {Marcus R.}",

year = "2014",

month = jun,

doi = "10.1111/add.12514",

language = "English",

volume = "109",

pages = "1013--1021",

journal = "Addiction",

issn = "0965-2140",

publisher = "Wiley",

number = "6",

}

TY - JOUR

T1 - Maternal smoking during pregnancy and offspring smoking initiation

T2 - Assessing the role of intrauterine exposure

AU - Taylor, Amy E.

AU - Howe, Laura D.

AU - Heron, Jon E.

AU - Ware, Jennifer J.

AU - Hickman, Matthew

AU - Munafo, Marcus R.

PY - 2014/6

Y1 - 2014/6

N2 - AimsTo assess whether associations between maternal smoking during pregnancy and offspring smoking initiation are due to intrauterine mechanisms.DesignComparison of associations of maternal and partner smoking behaviour during pregnancy with offspring smoking initiation using partner smoking as a negative control (n=6484) and a Mendelian randomization analysis (n=1020), using a genetic variant in the mothers as a proxy for smoking cessation during pregnancy.SettingA longitudinal birth cohort in South West England.ParticipantsParticipants of the Avon Longitudinal Study of Parents and Children (ALSPAC).MeasurementsSmoking status during pregnancy was self-reported by mother and partner in questionnaires administered at pregnancy. Latent classes of offspring smoking initiation (non-smokers, experimenters, late-onset regular smokers and early-onset regular smokers) were previously developed from questionnaires administered at 14-16 years. A genetic variant, rs1051730, was genotyped in the mothers.FindingsBoth mother and partner smoking were similarly positively associated with offspring smoking initiation classes, even after adjustment for confounders. Odds ratios (OR) [95% confidence interval (CI)] for class membership compared with non-smokers were: experimenters: mother OR=1.33 (95% CI=1.06, 1.67), partner OR=1.28 (95% CI=1.06, 1.55), late-onset regular smokers: mother OR=1.80 (95% CI=1.43, 2.26), partner OR=1.86 (95% CI=1.52, 2.28) and early-onset regular smokers: mother OR=2.89 (95% CI=2.12, 3.94), partner OR=2.50 (95% CI=1.85, 3.37). There was no clear evidence for a dose-response effect of either mother or partner smoking heaviness on class membership. Maternal rs1051730 genotype was not clearly associated with offspring smoking initiation class in pre-pregnancy smokers (P=0.35).ConclusionThe association between smoking during pregnancy and offspring smoking initiation does not appear to operate through intrauterine mechanisms.

AB - AimsTo assess whether associations between maternal smoking during pregnancy and offspring smoking initiation are due to intrauterine mechanisms.DesignComparison of associations of maternal and partner smoking behaviour during pregnancy with offspring smoking initiation using partner smoking as a negative control (n=6484) and a Mendelian randomization analysis (n=1020), using a genetic variant in the mothers as a proxy for smoking cessation during pregnancy.SettingA longitudinal birth cohort in South West England.ParticipantsParticipants of the Avon Longitudinal Study of Parents and Children (ALSPAC).MeasurementsSmoking status during pregnancy was self-reported by mother and partner in questionnaires administered at pregnancy. Latent classes of offspring smoking initiation (non-smokers, experimenters, late-onset regular smokers and early-onset regular smokers) were previously developed from questionnaires administered at 14-16 years. A genetic variant, rs1051730, was genotyped in the mothers.FindingsBoth mother and partner smoking were similarly positively associated with offspring smoking initiation classes, even after adjustment for confounders. Odds ratios (OR) [95% confidence interval (CI)] for class membership compared with non-smokers were: experimenters: mother OR=1.33 (95% CI=1.06, 1.67), partner OR=1.28 (95% CI=1.06, 1.55), late-onset regular smokers: mother OR=1.80 (95% CI=1.43, 2.26), partner OR=1.86 (95% CI=1.52, 2.28) and early-onset regular smokers: mother OR=2.89 (95% CI=2.12, 3.94), partner OR=2.50 (95% CI=1.85, 3.37). There was no clear evidence for a dose-response effect of either mother or partner smoking heaviness on class membership. Maternal rs1051730 genotype was not clearly associated with offspring smoking initiation class in pre-pregnancy smokers (P=0.35).ConclusionThe association between smoking during pregnancy and offspring smoking initiation does not appear to operate through intrauterine mechanisms.

KW - ALSPAC

KW - intrauterine

KW - maternal smoking

KW - Mendelian randomization

KW - negative control

KW - offspring smoking

KW - pregnancy

KW - tobacco

KW - PRENATAL NICOTINE EXPOSURE

KW - SELF-REPORTED SMOKING

KW - ADOLESCENT SMOKING

KW - TOBACCO EXPOSURE

KW - SUBSTANCE USE

KW - GENE-CLUSTER

KW - BEHAVIOR

KW - MOTHERS

KW - RISK

KW - METAANALYSIS

U2 - 10.1111/add.12514

DO - 10.1111/add.12514

M3 - Article (Academic Journal)

C2 - 24521169

SN - 0965-2140

VL - 109

SP - 1013

EP - 1021

JO - Addiction

JF - Addiction

IS - 6

ER -

Maternal smoking during pregnancy and offspring smoking initiation: Assessing the role of intrauterine exposure

Abstract

Bibliographical note

Research Groups and Themes

Keywords

Access to Document

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Projects

MRC UoB UNITE Unit - programme 3

MRC UoB UNITE Unit - Programme 6

Using Mendelian Randomisation to Establish the Causal Role of Cigarette Smoking in Anxiety and Depression

Cite this