Mathematical modeling of gonadotropin-releasing hormone signaling

Amitesh Pratap, Kathryn L Garner, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Craig A McArdle*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

21 Citations (Scopus)
275 Downloads (Pure)

Abstract

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control of reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.
Original languageEnglish
Pages (from-to)42-55
Number of pages14
JournalMolecular and Cellular Endocrinology
Volume449
Early online date17 Aug 2016
DOIs
Publication statusPublished - 5 Jul 2017

Keywords

  • ERK
  • GnRH
  • GPCR
  • Mathematical modeling
  • Mutual information
  • NFAT

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