Mathematical modeling of gonadotropin-releasing hormone signaling

Amitesh Pratap; Kathryn L Garner; Margaritis Voliotis; Krasimira Tsaneva-Atanasova; Craig A McArdle

doi:10.1016/j.mce.2016.08.022

Mathematical modeling of gonadotropin-releasing hormone signaling

Amitesh Pratap, Kathryn L Garner, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Craig A McArdle^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control of reproduction. These are G_q-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.

Original language	English
Pages (from-to)	42-55
Number of pages	14
Journal	Molecular and Cellular Endocrinology
Volume	449
Early online date	17 Aug 2016
DOIs	https://doi.org/10.1016/j.mce.2016.08.022
Publication status	Published - 5 Jul 2017

Research Groups and Themes

Engineering Mathematics Research Group

Keywords

ERK
GnRH
GPCR
Mathematical modeling
Mutual information
NFAT

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10.1016/j.mce.2016.08.022

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@article{96e934e4a05345efac95065ee28807fe,

title = "Mathematical modeling of gonadotropin-releasing hormone signaling",

abstract = "Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control of reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.",

keywords = "ERK, GnRH, GPCR, Mathematical modeling, Mutual information, NFAT",

author = "Amitesh Pratap and Garner, \{Kathryn L\} and Margaritis Voliotis and Krasimira Tsaneva-Atanasova and McArdle, \{Craig A\}",

year = "2017",

month = jul,

day = "5",

doi = "10.1016/j.mce.2016.08.022",

language = "English",

volume = "449",

pages = "42--55",

journal = "Molecular and Cellular Endocrinology",

issn = "0303-7207",

publisher = "Elsevier Science Ireland",

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TY - JOUR

T1 - Mathematical modeling of gonadotropin-releasing hormone signaling

AU - Pratap, Amitesh

AU - Garner, Kathryn L

AU - Voliotis, Margaritis

AU - Tsaneva-Atanasova, Krasimira

AU - McArdle, Craig A

PY - 2017/7/5

Y1 - 2017/7/5

N2 - Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control of reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.

AB - Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control of reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.

KW - ERK

KW - GnRH

KW - GPCR

KW - Mathematical modeling

KW - Mutual information

KW - NFAT

UR - https://www.scopus.com/pages/publications/84994885307

U2 - 10.1016/j.mce.2016.08.022

DO - 10.1016/j.mce.2016.08.022

M3 - Article (Academic Journal)

C2 - 27544781

SN - 0303-7207

VL - 449

SP - 42

EP - 55

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

ER -

Mathematical modeling of gonadotropin-releasing hormone signaling

Abstract

Research Groups and Themes

Keywords

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Computational Approaches to In Vivo Cell Signalling: Inference, Network Structure and Dynamic Decision-Making

Decoding gonadotropin-releasing hormone (GnRH) pulse frequency

Roles and interdependence of calcineurin/NFAT and ERK pathways in pulsatile GnRH effects on gonadotrophin expression.

Cite this

Mathematical modeling of gonadotropin-releasing hormone signaling

Abstract

Research Groups and Themes

Keywords

Access to Document

Handle.net

Other files and links

Fingerprint

Projects

Computational Approaches to In Vivo Cell Signalling: Inference, Network Structure and Dynamic Decision-Making

Decoding gonadotropin-releasing hormone (GnRH) pulse frequency

Roles and interdependence of calcineurin/NFAT and ERK pathways in pulsatile GnRH effects on gonadotrophin expression.

Cite this