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Mathematical modeling of gonadotropin-releasing hormone signaling

Research output: Contribution to journalArticle

  • Amitesh Pratap
  • Kathryn L Garner
  • Margaritis Voliotis
  • Krasimira Tsaneva-Atanasova
  • Craig A McArdle
Original languageEnglish
Pages (from-to)42-55
Number of pages14
JournalMolecular and Cellular Endocrinology
Volume449
Early online date17 Aug 2016
DOIs
DateAccepted/In press - 11 Aug 2016
DateE-pub ahead of print - 17 Aug 2016
DatePublished (current) - 5 Jul 2017

Abstract

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control of reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.

    Research areas

  • ERK, GnRH, GPCR, Mathematical modeling, Mutual information, NFAT

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Elsevier at http://www.sciencedirect.com/science/article/pii/S0303720716303161. Please refer to any applicable terms of use of the publisher.

    Final published version, 1.73 MB, PDF document

    Licence: CC BY

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